FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice

B Zhang, J Li, X Zong, J Wang, L Xin… - PLOS Neglected …, 2022 - journals.plos.org
… a hepatocyte-specific FXR KO mouse using the Cre-flox … of mature granulomas after 6
wpi in C57BL/6 mice, thus, the … main primary bile acids. In mice, taurocholate- conjugated …

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet

OAHO Ronda, BJM van de Heijning, A de Bruin… - PLoS …, 2020 - journals.plos.org
… The widely available C57BL/6 mouse strain is the most commonly used inbred … by an
infection; we did observe the two phenotypes also within individual cages, housing different mice. …

Mouse models of liver fibrosis

A Ravichandra, RF Schwabe - Myofibroblasts: Methods and Protocols, 2021 - Springer
… While the majority of studies are done in C57BL/6 mice due … cholestasis (PFIC3) and
primary sclerosing cholangitis (PSC) [16]. … to minimize the risk of infection and cross-contamination. …

Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis

Y Yang, Y Chen, Y Zhao, F Ji, L Zhang, S Tang… - Stem Cell Research & …, 2022 - Springer
liver injury mainly includes primary biliary cirrhosis (PBC) … C57BL/6 mice were randomly
divided into different groups and … and AAV-shCtnnb1 infected liver tissues of different groups (n …

Animal models for autoimmune hepatitis: are current models good enough?

U Christen, E Hintermann - Frontiers in Immunology, 2022 - frontiersin.org
liver diseases like autoimmune hepatitis, primary biliary cholangitis, primary sclerosing
cholangitis, and IgG4-related … only infection of NOD, but not C57BL/6 resulted in AIH-like disease. …

Animal models of hepatitis B virus infection–success, challenges, and future directions

Y Liu, S Maya, A Ploss - Viruses, 2021 - mdpi.com
… obtain a mouse model that can be directly infected with HBV … a similar immune response
against viral infection to humans. … detected in the liver of AAV-HBV transduced C57BL/6 mice, …

The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts

T Liwinski, M Heinemann, C Schramm - Seminars in Immunopathology, 2022 - Springer
… , primary biliary cholangitis, and primary sclerosing cholangitis… the human betaretrovirus
or the structurally related murine … linked PSC with HCV infection and human T-lymphotropic …

Gut microbiota contributes to sexual dimorphism in murine autoimmune cholangitis

MX Huang, SY Yang, PY Luo, J Long… - Journal of Leukocyte …, 2021 - academic.oup.com
… that a transgenic murine model of primary biliary cholangitis (PBC), … Different immune cell
profiles of the liver in male and female … of microbes at different parts of the body. The microbiota …

A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis

X Jiang, A Bergquist, BS Löscher… - Science Translational …, 2021 - science.org
… that different causal factors exist that drive similar biliaryHuman CD100 is one amino
acid longer than mouse CD100… All mice were on a C57BL/6 background and bred in-house. …

[HTML][HTML] Recent developments in etiology and disease modeling of biliary atresia: a narrative review

A Malik, U Thanekar, R Mourya… - Digestive medicine …, 2020 - ncbi.nlm.nih.gov
body of existing literature points to a potential viral infection … available exclusively in the
C57BL/6 background for mechanistic … of ascending cholangitis or secondary biliary cirrhosis but …