… glomerulopathy, uncontrolled complement activation is the primary driver of disease. … was
also found that C3 is deposited in the glomeruli of patients with lupus nephritis. These findings …

… includes dense deposit disease (DDD) and C3 glomerulonephritis (… Serum/plasma/DNA
samples were isolated and stored at –80… and gene variants for C3G/atypical haemolytic uraemic …

… well-characterized clinicopathologic entities, such as AL … those with underlying genetic
susceptibility to a primary TMA (… deposit disease (DDD) and C3 glomerulonephritis (C3GN). …

… clinical observations indicates a primary role of the activation … /haemolytic uraemic
syndrome/atypical haemolytic uraemic … proliferative glomerulonephritis with IgA, C3 deposits and …

… haemolytic–uraemic syndrome, diabetic kidney disease and … primary drivers of disease in
atypical haemolytic–uraemic … The detection of glomerular C3 deposits in the absence of C4d …

… A male primary school age child presented with a history of 3–… of C3 and associated fragments
may then be deposited in … in patients with atypical haemolytic uraemic syndrome (aHUS). …

… are classified as primary TMA when genetic and acquired … of FH, factor D, and factor I can
clarify the mechanism of C3 … In addition, soluble and glomerular deposits of C5b-9 have been …

… There is overlap between primary and secondary TMA. Of 66 … be present, but electron dense
deposits are not identified. … underlying glomerulopathies, C3 glomerulonephritis might be an …

… , C3 glomerulopathy is a recently described entity which includes both the dense deposit
disease (DDD) and C3 GN. … On light microscopy, both share common histological features like …

… coagulation is antithrombin, the primary inhibitor of thrombin, … to controls showed increased
C3 deposits and a larger area … haemolytical uremic syndrome and their possible connection …