[HTML][HTML] Heme degradation in pathophysiology of and countermeasures to inflammation-associated disease

DD Haines, A Tosaki - International Journal of Molecular Sciences, 2020 - mdpi.com
… deposits of heme accumulate as a result of the removal of … in a process that results in further
release of heme into the plasma … lipid peroxides and protein aggregates, resulting in DNA …

Heme determination and quantification methods and their suitability for practical applications and everyday use

MT Hopp, BF Schmalohr, T Kühl, MS Detzel… - 2020 - ACS Publications
… permanently bound heme and its high aggregation potential. Thus, … in the context of the
removal of senescent RBCs from the … to hemochromogen, which results in inaccurate analysis. …

[HTML][HTML] Linking labile heme with thrombosis

MT Hopp, D Imhof - Journal of clinical medicine, 2021 - mdpi.com
… the results with the actual maximal plasma heme concentrations [177… to reduce heme, but
did not affect platelet aggregation due to … was gained by the fact that removal of calcium ions by …

[HTML][HTML] Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions

V Consoli, V Sorrenti, S Grosso, L Vanella - Biomolecules, 2021 - mdpi.com
aggregation of proteins in non-native conformations. … whose results showed that
immunosuppressive HO-1-specific … of metabolic enzymes to eliminate these derivates, suggesting …

[HTML][HTML] The worst things in life are free: the role of free heme in sickle cell disease

OT Gbotosho, MG Kapetanaki, GJ Kato - Frontiers in immunology, 2021 - frontiersin.org
… Red cell destruction may occur as a result of a hereditary … Our results of heme-induced
IL-6 is in agreement with elevated … Protein aggregation as a cellular response to oxidative …

[HTML][HTML] Pro-inflammatory actions of heme and other hemoglobin-derived DAMPs

MT Bozza, V Jeney - Frontiers in Immunology, 2020 - frontiersin.org
aggregates containing ubiquitinated proteins (100, 101). The … hemolysis the Hb-heme
elimination system is largely … vivo resulting that the outcome of heme pretreatment largely …

Photomedicine based on heme-derived compounds

H Keum, D Yoo, S Jon - Advanced Drug Delivery Reviews, 2022 - Elsevier
… to color in this figure legend, the reader is referred to the web … show only limited improvement
in in vivo PDT outcome in the … , such as photostability and aggregating properties, are …

[HTML][HTML] Linking COVID-19 and heme-driven pathophysiologies: A combined computational–experimental approach

MT Hopp, D Domingo-Fernandez, Y Gadiya, MS Detzel… - Biomolecules, 2021 - mdpi.com
… analyzing a potential link between heme-related and COVID-… In the following, we present
our results concerning a detailed … ], whereas for heme, an induction of platelet aggregation was …

The receptor for advanced glycation end products is a sensor for cell‐free heme

O May, L Yatime, NS Merle, F Delguste… - The FEBS …, 2021 - Wiley Online Library
… Moreover, we observed that heme aggregates in the form of … our results, our in vivo experiments
show that heme induced … chromatography on a nickel column with removal of the His 6 -…

[HTML][HTML] Irreversible alterations in the hemoglobin structure affect oxygen binding in human packed red blood cells

E Szczesny-Malysiak, J Dybas, A Blat, K Bulat… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… in α-helices related to the aggregation process stabilized by strong … Within each Hb subunit
there is an incorporated heme group … Our results shed a new light on the alterations in RBCs …