Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents

SA Johnson, T Fang, F De Marchi, D Neel… - Drugs, 2022 - Springer
… of bringing new treatments to market [18]. Here, we review the existing ALS pharmacology
and … Previous Phase 2 trials provided evidence to support the safety and tolerability of each …

Advances in disease-modifying pharmacotherapies for the treatment of amyotrophic lateral sclerosis

R Hergesheimer, D Lanznaster, P Vourc'h… - … on Pharmacotherapy, 2020 - Taylor & Francis
… ALS clinical trials with the new and upcoming therapeutic strategies. Once the network
among … a large, expensive, and time-consuming phase III trial possesses a promising outlook. …

[HTML][HTML] Exploring Advancements in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review of Current Modalities and Future Prospects

P Hoxhaj, N Hastings, MP Kachhadia, R Gupta… - Cureus, 2023 - ncbi.nlm.nih.gov
… We used a Pubmed search strategy and specific MeSH terms for the selection of the literature
articles using the keywords "ALS," "new treatment," "treatment," and "symptomatic treatment

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
… intravenous formulation in the treatment of patients with ALS. … modelling which improve
the prospects for identification of … suggest strategies to address the huge unmet need for new

[HTML][HTML] Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies

LM Gittings, R Sattler - Faculty reviews, 2020 - ncbi.nlm.nih.gov
… trials for the treatment of amyotrophic lateral sclerosis. … This is an effective strategy already
used in the treatment of … further additions or exclusions of new therapies or patient populations …

Prospects for gene replacement therapies in amyotrophic lateral sclerosis

I Giovannelli, A Higginbottom, J Kirby… - Nature Reviews …, 2023 - nature.com
… for the treatment of this … strategies for ALS and describe disease-associated loss-of-function
(LoF) mutations that could represent new future targets for gene replacement strategies

Potential of cellular therapy for ALS: current strategies and future prospects

TJ Lin, KC Cheng, LY Wu, WY Lai, TY Ling… - Frontiers in Cell and …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
… Recently, cellular therapy has been the new hope for ALS treatment by targeting multiple

Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as neurodegenerative diseases and their treatments: a review study

O Deeb, M Nabulsi - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
… engagement strategies and individualization of treatment are … exploring new improved
treatment options due to side effects… timing and the possibilities of changing the treatment regimen …

Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis

L Martinez-Gonzalez, A Martinez - Expert Opinion on …, 2023 - Taylor & Francis
… during years as a therapeutic strategy for ALS is oxidative … the safety and side effects of
the new treatment but the main … increasing the possibilities to provide effective drugs for ALS. …

Pharmacological Management of Amyotrophic Lateral Sclerosis

S Mani, C Kubba, T Sharma… - Advances in …, 2020 - taylorfrancis.com
… presently being implemented for ALS treatment. To manage the … made toward the development
of new ALS therapy, from the … antioxidative methods. It further highlights the outcomes of …