… , is strongly linked to advanced prostate cancer progression and … Loss of the tumor suppressor
PTEN is commonly observed in … shown in mice that Pten homozygous deletion and an …

… PTEN is a tumor suppressor gene and one of the most … PTEN deletion has been highly
linked to inflammation, in … role of PTEN in PCa, a PTEN prostate-specific deletion mouse model …

… genetic modification specifically in the prostate gland, we used mice expressing the recombinase
Cre driven by the prostate-specific … of PTEN leads to the inhibition of AR-induced gene …

… prostate cancer upon loss of PTEN expression. Hence, combined prostate-specific Pten and
Smad4 knockout led … with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8: …

… The prostate-specific Pten-KO mouse model resembles many … (AR) and P53 tumor
suppressor in the early lesions and … showed that Pten-KO in the mouse prostate epithelium led to …

… as a novel tumor suppressor gene and prognostic biomarker … malignancy and the second
leading cause of cancer-related death … , we established a murine orthotopic Frmd6/Pten double-…

… by the tumor suppressor gene PTEN. Mutations in this … , leading to the deletion of the floxed
Pten gene in the prostate … this present mouse model, the prostate-specific Cre-LoxP gene …

… Loss of the tumor suppressor gene Pten in murine prostate … Prostate-specific loss of the tumor
suppressor gene Pten … First, we observed that prostate-specific Fasn deletion is associated …

… mouse model of prostate cancer based on prostate-specific … of its negative regulator and
tumor suppressor gene, … We also asked if the loss of Trp53 with Pten lead to an increase in …

… and metastasis [13]. The tumor suppressor, phosphatase and tensin homolog deleted on …
B–D: Three different stages of tumor progression in the Pten mouse prostate tumors. B: …