Protective effect of dapsone against bleomycin-induced lung fibrosis in rat
H Yousefi-Manesh, T Noori, MH Asgardoon… - Experimental and …, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disease of the lung tissue that
causes symptoms such as coughing and asthma. It is caused by inflammatory factors and
oxidative stress. In vivo model of IPF is induced by bleomycin (BLM,) a chemotherapeutic
agent. We have investigated the effect of dapsone on bleomycin-induced IPF in adult male
Wistar rats due to its anti-inflammatory and anti-oxidative stress effects. The animals were
randomly divided into 5 groups (Control, BLM, BLM+ dapsone 1, BLM+ Dapsone 3, BLM+ …
causes symptoms such as coughing and asthma. It is caused by inflammatory factors and
oxidative stress. In vivo model of IPF is induced by bleomycin (BLM,) a chemotherapeutic
agent. We have investigated the effect of dapsone on bleomycin-induced IPF in adult male
Wistar rats due to its anti-inflammatory and anti-oxidative stress effects. The animals were
randomly divided into 5 groups (Control, BLM, BLM+ dapsone 1, BLM+ Dapsone 3, BLM+ …
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