Clinical significance of phospholipase A2 in glaucoma

A Mandal, MV Varghese, J James - Phospholipases in Physiology and …, 2023 - Elsevier
… the protective role of … -specific inhibitors have been emerging as potential therapeutic
interventions to treat glaucoma. Those inhibitors are used as alternate strategies to replace steroids

[PDF][PDF] Secretory phospholipase A2 group IIA: a potential therapeutic target in inflammation

AS Giresha - Current Research and Trends in Medical Science …, 2021 - researchgate.net
… However, effective and specific inhibitors of sPLA2GIIA are still not available to date. …
However, the protective inflammatory reactions become detrimental when the inflammatory …

Phospholipase A2 as a modulator of infection, inflammation, and immunity

UN Das - Phospholipases in Physiology and Pathology, 2023 - Elsevier
… cells produce a specific combination of effector cytokines that bring about specific and distinct
… ) along with corticosteroids is recommended so that their (corticosteroids) antiinflammatory …

[PDF][PDF] Amelioration of doxorubicin-Induced liver and kidney toxicities by nicorandil alone and co-administered with prednisolone and diltiazem

AJ Akindele, KI Amagon, GT Ekundayo… - Proceedings of the …, 2020 - researchgate.net
calcium channel blocker/phospholipase A2 inhibitor did not elicit superior protective effect. …
The findings in this study in respect of ALT, a more specific liver enzyme, suggest that …

The phospholipase A2 superfamily: structure, isozymes, catalysis, physiologic and pathologic roles

SA Khan, MA Ilies - International journal of molecular sciences, 2023 - mdpi.com
… of corticosteroids to treat the inflammation [123]. … phospholipase A2 comprises a very diverse
collection of members, evolved to perform the same hydrolytic reaction in different specific

Phospholipases A2

SA Khan, MA Ilies - Metalloenzymes, 2024 - Elsevier
… human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX). …
Inhibition of iPLA2 activity by specific inhibitor bromoenol lactone (BEL) reduced nicotine-…

Pharmacological modulation of calcium in selective cardiovascular disorders through store operated calcium entry inhibitors

HH Savsani - 2021 - search.proquest.com
… , Myocardial ischemia and reperfusion injury through Store operated calcium channel blocker.
… Results: Selected plant extracts have high total phenolics and total flavonoids content. …

Mechanisms providing effects of cardiotonic steroids in mammalian cells with special attention to blood cells

YM Poluektov, OD Lopina, MA Strelkova, ID Kuleshova… - 2023 - preprints.org
protective effect of CTS [70]. Under hypoxia conditions, the … of mice was blocked by a specific
NF-κB inhibitor. Since it was … via phosphorylation of calcium-bound phospholipase A2 [135]…

[图书][B] Phospholipases in Physiology and Pathology

S Chakraborti - 2023 - books.google.com
… ; these sn positions are the stereospecific numbering of fatty acid esterification to the glycerol
… (IP3) channels to the endoplasmic reticulum and binds to its receptor on calcium channels

Neuroaxonal and cellular damage/protection by prostanoid receptor ligands, fatty acid derivatives and associated enzyme inhibitors

NA Sharif - Neural Regeneration Research, 2023 - journals.lww.com
… Arachidonic acid formed by the action of phospholipase A2 … The search strategy and selection
criteria utilized keywords … a recent report that illustrates protective effects of an EP 2 /EP 3 …