[HTML][HTML] Protein Kinase C-delta Inhibition is Organ-Protective, Enhances Pathogen Clearance and Improves Survival in Sepsis

E Liverani, SA Tursi, WD Cornwell… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
… with isotype control antibodies as background controls. Cells … inflammation and damage to
the lungs that is evident at 24 hr … White blood cell counts were analyzed in the BAL fluid at 24 …

Complement receptors and their role in leukocyte recruitment and phagocytosis

S Vandendriessche, S Cambier, P Proost… - Frontiers in Cell and …, 2021 - frontiersin.org
leukocytes and parenchymal cells, which, by recognizing complement-derived molecules,
promote leukocyte recruitment, … of inflammation and bone loss compared to control mice, even …

Biomaterial-driven immunomodulation: cell biology-based strategies to mitigate severe inflammation and sepsis

JJM Lasola, H Kamdem, MW McDaniel… - Frontiers in …, 2020 - frontiersin.org
… , the example of activated protein C therapies and other failed clinical … by LPS stimulation
and improved survival in lethal LPS-… at the inflamed site beyond what is needed to control the …

C-reactive protein and cancer—diagnostic and therapeutic insights

PC Hart, IM Rajab, M Alebraheem… - Frontiers in …, 2020 - frontiersin.org
… of leukocytes can also favor a state of chronic inflammation that conversely would promote
genomic instability, survival, and … The goal of this early response is to help control the extent of …

How to explain the beneficial effects of leukocyte‐and platelet‐rich fibrin

J Blanco, A García Alonso… - Periodontology …, 2024 - Wiley Online Library
survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents,
and inflammation… difference was observed between control group (spontaneous healing) …

Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness

WE Plautz, ZA Matthay, MA Rollins‐Raval… - …, 2020 - Wiley Online Library
… normal levels of activated protein C.Importantly, TIC was … vWF forms when compared to
healthy controls.Altogether, these … binding domain peptide increases survival in septic rodents. …

Oxidative stress and endothelial dysfunction in sepsis and acute inflammation

J Joffre, J Hellman - Antioxidants & redox signaling, 2021 - liebertpub.com
… inhibitor (TFPI), EC protein C receptor, and thrombomodulin, … , the control group received
lower doses of vitamins C and E … vascular permeability and leukocyte recruitment, and …

Increased alternative complement pathway function and improved survival during critical illness

W Bain, H Li, R van der Geest, SR Moore… - American journal of …, 2020 - atsjournals.org
… 30-day mortality and improved 1-year survival. Patients with … fewer bloodstream infections
and improved serum control of a … Therefore, we classified the inflammatory subphenotypes of …

A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics

V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
control are countered by pro-inflammatory effects as demonstrated in a variety of diseases.
Components of NETS are non-specific, and other than controlling … diseases improving survival

Serum amyloid A proteins and their impact on metastasis and immune biology in cancer

J Lee, GL Beatty - Cancers, 2021 - mdpi.com
… supports the recruitment of inflammatory leukocytes and in … of pro-inflammatory cytokines
and improved survival [97]. Thus, … cancer inflammation cycle and may act as rheostat to control