Translocation of proteins through a distorted lipid bilayer
X Wu, TA Rapoport - Trends in cell biology, 2021 - cell.com
… membrane is overcome in different protein translocation systems. We begin with the classic
Sec system in which translocation … large variety of proteins across membranes. Accordingly, …
Sec system in which translocation … large variety of proteins across membranes. Accordingly, …
Mechanisms of energy transduction by charge translocating membrane proteins
… translocation across the membrane. This hypothesis was extended to photosynthetic systems,
in which membrane … can also be established by light-driven charge-translocating proteins. …
in which membrane … can also be established by light-driven charge-translocating proteins. …
Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria
J Vergalli, IV Bodrenko, M Masi, L Moynié… - Nature Reviews …, 2020 - nature.com
… , OmpF is required for the entry of colicin toxins; specifically the cell surface exposed loops
of porins are involved in the translocation of colicin A and E3 across the outer membrane 13 . …
of porins are involved in the translocation of colicin A and E3 across the outer membrane 13 . …
An ER translocon for multi-pass membrane protein biogenesis
PT McGilvray, SA Anghel, A Sundaram, F Zhong… - Elife, 2020 - elifesciences.org
… with Sec61 could access the membrane through the conserved cytosolic TMCO1 … have
translocated across the bilayer through the canonical Sec61 channel might access the membrane …
translocated across the bilayer through the canonical Sec61 channel might access the membrane …
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein
WK Tang, MJ Borgnia, AL Hsu, L Esser, T Fox… - Nature structural & …, 2020 - nature.com
… Protein unfolding and translocation across the membranes are biological processes essential
for cellular functions. Although different cellular machineries are employed to drive the two …
for cellular functions. Although different cellular machineries are employed to drive the two …
Take me home, protein roads: Structural insights into signal peptide interactions during ER translocation
AM Liaci, F Förster - International Journal of Molecular Sciences, 2021 - mdpi.com
… Additionally, some Sec62/63-dependent substrates possess a positively charged cluster in
the mature region that likely impairs the translocation across the Sec61 channel [62]. Notably, …
the mature region that likely impairs the translocation across the Sec61 channel [62]. Notably, …
The mechanisms of integral membrane protein biogenesis
RS Hegde, RJ Keenan - Nature reviews Molecular cell biology, 2022 - nature.com
… to be translocated by providing a continuous aqueous conduit across the membrane. b | …
an aqueous channel for protein translocation and a lateral gate for membrane insertion of …
an aqueous channel for protein translocation and a lateral gate for membrane insertion of …
Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood–Brain Barrier Model
… Although the translocation is always low, our data suggest that size and targeting … NP
translocation across the BBB. As a platform that enables the detection of rare transmission across …
translocation across the BBB. As a platform that enables the detection of rare transmission across …
The SecA motor generates mechanical force during protein translocation
R Gupta, D Toptygin, CM Kaiser - Nature Communications, 2020 - nature.com
… proteins across lipid bilayers in all cells. The Sec channel enables passage of unfolded
proteins through the bacterial plasma membrane, … 1 transports proteins across membranes in all …
proteins through the bacterial plasma membrane, … 1 transports proteins across membranes in all …
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins
L Kater, N Wagener, O Berninghausen… - Nature Structural & …, 2020 - nature.com
… Proteins are translocated across membranes mostly in an unfolded state. In this mode, canonical
protein… plethora of different soluble and membrane proteins as mostly uniform extended …
protein… plethora of different soluble and membrane proteins as mostly uniform extended …
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