[HTML][HTML] Proteomic analysis of Huntington's disease medium spiny neurons identifies alterations in lipid droplets
KT Tshilenge, CG Aguirre, J Bons, AA Gerencser… - Molecular & cellular …, 2023 - ASBMB
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat
expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the
function of the HTT protein. Although HTT is expressed in different tissues, the medium-spiny
projection neurons (MSNs) in the striatum are particularly vulnerable in HD. Thus, we sought
to define the proteome of human HD patient–derived MSNs. We differentiated HD72-
induced pluripotent stem cells and isogenic controls into MSNs and carried out quantitative …
expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the
function of the HTT protein. Although HTT is expressed in different tissues, the medium-spiny
projection neurons (MSNs) in the striatum are particularly vulnerable in HD. Thus, we sought
to define the proteome of human HD patient–derived MSNs. We differentiated HD72-
induced pluripotent stem cells and isogenic controls into MSNs and carried out quantitative …
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