Differential Expression of microRNA Profiles and Wnt Signals in Stem Cell-Derived Exosomes During Dopaminergic Neuron Differentiation

T Jin, J Gu, H Xia, H Chen, X Xu, Z Li, Y Yue… - DNA and Cell …, 2020 - liebertpub.com
… Exosome isolation and purificationWnt5a can mediate DA differentiation by activating
Wnt/PCP/Rac1 … time that the Wnt5a, Wnt5b, Wnt7a, and Wnt9a mRNAs were increased in EpiSC-…

… repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's …

JM Haynes, SM Sibuea, AA Aguiar, F Li, JK Ho… - Plos one, 2021 - journals.plos.org
dopaminergic neuron differentiation paradigms and/or purify … , 2, 4 & 5), dickkopfs (DKK1, 2,
3 & 4), disheveled (DVL1, DVL2… of an A9 midbrain dopaminergic phenotype while increasing

Want of Wnt in Parkinson's disease: Could sFRP disrupt interplay between Nurr1 and Wnt signaling?

N Gamit, A Dharmarajan, G Sethi, S Warrier - Biochemical Pharmacology, 2023 - Elsevier
… or 6 (Lrp5/6) co-receptors, followed by recruitment of dishevelled (Dvl) and … and differentiation
of DA neurons. Neuroepithelial cells in Nurr1 knockout model gave rise to DA neurons that …

[HTML][HTML] Microglial WNT5A supports dendritic spines maturation and neuronal firing

H Yeh, ME Woodbury, KLI Dixie, T Ikezu… - Brain, behavior, and …, 2023 - Elsevier
WNT family member 5A (WNT5A) is the most abundant WNT … + differentiated neurons
significantly increased neuronal … following removal of the cerebellum and brainstem and placed in …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
… protein (LRP) 5/6 coreceptors and Dishevelled (Dvl) and Axin … fold increase in precursor
differentiation into DAergic neurons… Here, direct coculture of young NSCs with purified microglia …

Wnt signaling in stem cells during development and cell lineage specification

R Chidiac, S Angers - Current Topics in Developmental Biology, 2023 - Elsevier
… , which triggers the recruitment of Disheveled (DVL) to the plasma … of Wnt/β-catenin by a
variety of means (purified Wnt3a … by the Wnt, BMP, NODAL and FGF family of secreted growth

WNT5a regulates epithelial morphogenesis in the developing choroid plexus

MB Langford, CJ O'Leary, L Veeraval, A White… - Cerebral …, 2020 - academic.oup.com
… of the molecular and cellular processes giving rise to the CPs … agarose gel electrophoresis
and purified using the Wizard SV … no significant difference in the number of BrdU-positive cells

Unravelling the Wnt-3a Signalling Mechanisms that Modulate Inflammation and Neurodegeneration in Cell Cultures and in an Animal Model of Parkinson's Disease

G Federici - 2021 - search.proquest.com
… in striatal dopamine. Currently, there is no longP term treatment for PD and therapies are
mainly symptomatic without any slowing of dopaminergic neuron degeneration. An increasing

Wnt signaling

PC Salinas - Synapse Development and Maturation, 2020 - Elsevier
… revealed why these secreted proteins are difficult to purify. … to the Fz and coreceptor LRP5 or
LRP6 activates dishevelled (Dvl) … conditions raises the interesting possibility that Wnts act as …

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

A Coschiera, M Yoshihara, G Lauter, S Ezer, M Pucci… - BMC biology, 2024 - Springer
… A The percentage of ciliation in differentiating human LUHMES neurons increases once …
pronouncedly weaker similarity with differentiating human midbrain neurons as compared to WT…