… Proteomic analysis combined with metabolomics also indicated that chronic paroxetine (SSRI)
treatment affects purine, pyrimidine, glutamatergic, and ubiquitin-proteasome system, …

… in amino acid metabolism, nervous system signaling/neurotransmitters, and nucleotide
metabolism. In … This study provides important clues for the metabolic characteristics of the PFC in …

… the metabolic impact in males and 75% in females came from abnormalities in lipids. Modified
purines and pyrimidines from … revealed a convergence of many abnormalities in treatment-…

… Moreover, we summarized the metabolites associated with antidepressant treatment
responses. Keywords used for the literature searches were ‘depression’ [MeSH] and ‘metabolomics…

… and can impair metabolic homeostasis. The one-carbon cycle (1-CC) metabolism and amino
acid (… In this study, we investigated the Paroxetine treatment effect on the plasma metabolite …

… Therefore, the AD-like mechanism of chronic minocycline treatment is maybe due to the …
indicated that chronic paroxetine (SSRI) treatment affects purine, pyrimidine, glutamatergic, …

… , antidepressant medicines are widely used to treat … influencing the efficacies of
antidepressants. Thus, further studies … in non-responsive treatment of antidepressants. Together, …

… (SSRI) treatments. Using paroxetine, a SSRI, the authors observed decreased purine
and pyrimidine metabolism in antidepressant non-responders, and increased metabolism in …

… Purine and pyrimidine metabolism have been associated with … 33 and antidepressant
treatment response. Citation34 Hence, carbohydrate metabolism and nucleotide metabolism might …

… in purine metabolism and pyrimidine metabolism pathways. Increased levels of uric acid,
an end product of the purine metabolism … represented accelerated purine degradation in …