[PDF][PDF] Annotated review on various biological activities of quinoline molecule

T Kaur, DD Bhandari - Biointerface Res. Appl. Chem, 2023 - biointerfaceresearch.com
Quinoline is a heterocyclic aromatic organic compound with … This pharmacological diversity
of quinoline has attracted … In the present review, we are outlining the potential of quinoline as …

A quinquennial review on recent advancements and developments in search of anti-malarial agents

TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - benthamdirect.com
… of the compound and among the fifteen derivatives, compound (18) containing the p-ethoxyphenyl
group on … The mainstay of anti-malarial therapy is quinolinecontaining drugs such as …

Amide tethered 4-aminoquinoline-naphthalimide hybrids: a new class of possible dual function antiplasmodials

Shalini, S Kumar, M Gendrot, I Fonta… - ACS medicinal …, 2020 - ACS Publications
… already generated severe resistance against quinoline based molecules. In … compound,
8e, with monomeric heme. In a nutshell, a solution of hemin in 40% DMSO/water shows a band

Quinoline containing side-chain antimalarial analogs: Recent advances and therapeutic Application

MC Joshi, TJ Egan - Current Topics in Medicinal Chemistry, 2020 - ingentaconnect.com
… The free NH2 group of compound 8 was then protected using di-tertbutyldicarbonate (Boc2O)
in DCM and Et3N as a base to furnish compound 9 [28] which was further reduced by …

Recent Updates in chemistry of quinoline analogs as potential antimalarial agent with utilization of Chem3D software

J Singh, A Chitranshi, UA Malla, P Kumar - International Journal of …, 2023 - ijphi.com
… of quinoline-sulfonamide hybrid compounds as potential antimalarial medications. These
compounds have different linker groups … with dibenzyl methylamine (dibemethin) side chains …

Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical …

J Okombo, M Kumar, D Redhi, KJ Wicht… - ACS Infectious …, 2023 - ACS Publications
… Moreover, the benzylamine/benzylmethylamine side groups appended to the quinoline core
can also adopt a planar conformation that would contribute to π-π interactions and potential …

Discovery and Development of Antimalarial Drug Resistance Reversal Agents

P Moyo, V Maharaj, SM Mutombo… - Frontiers in Anti …, 2024 - benthamdirect.com
quinoline drugs as well as the re-use of old antimalarial … (dibemethin) side chains [64, 65]
and these compounds were equally … ) and 44 (containing 3-chlorophenyl and 3-pyridyl groups). …

The cinchona alkaloids and the aminoquinolines

SL Rawe, C McDonnell - Antimalarial Agents, 2020 - Elsevier
… The bark also contains numerous minor quinoline derivatives including quinicine (5) (also …
which the chloro group was at position 6 of the quinoline ring resulted in a compound that was …

[HTML][HTML] Functionalized 3-hydroxy-3-aminoquinoline-oxindole hybrids as promising dual-function anti-plasmodials

B Sharma, J Legac, N Cele, P Awolade… - European Journal of …, 2022 - Elsevier
… Our research group recently reported that … the quinoline's potency against the highly
resistant strain [37,38]. The design of present set of scaffolds is based on integrating the quinoline

[HTML][HTML] Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors

I Irfan, A Uddin, R Jain, A Gupta, S Gupta, JV Napoleon… - Heliyon, 2024 - cell.com
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant
plasmodium falciparum and inhibit chloroquine transport via the P. falciparum …