… Another ubiquitin E3 ligase linking protein homeostasis and ageing is the quality control …
inates DAF-16, the worm FOXO, counteracting polyubiquitination by RLE-1 E3 ligase and its sub…

… E3 ubiquitin ligase, Regulation of Longevity by E3 (RLE-1) has previously been identified in
the modulation of aging by the ubiquitination of DAF-16 [… through monoubiquitination, where …

… For instance, the E3 ubiquitin ligase CHIP regulates the levels of DAF-2 through its ubiquitination
… Downregulation of RLE-1 E3 ligases results in less polyubiquitination of DAF-16, and …

… Such mechanisms may involve the synergy between DAF-16 and additional TFs, enabling
DAF-16 to selectively activate or repress a specific group of genes. This hypothesis gains …

… DAF-16 is SUMOylated, and that this modification represses the transcriptional activity of
DAF-16… that activation of SKN-1 negatively regulates DAF-16, which is in agreement with our …

… Recently, we characterized the Caenorhabditis elegans ortholog of Regnase-1, which we …
that might be regulated independently of RLE-1. Conversely, RLE-1 is likely to regulate other …

… RLE-1, a E3 ubiquitin ligase, catalyses ubiquitination of … elegans, catalysing the conversion
of GTP to cGMP. In … Altogether, this implies the daf-16 regulated induction of L1 arrest by …

… For instance, the E3 ubiquitin ligase CHIP regulates the levels of DAF-2 through its ubiquitination
… Downregulation of RLE-1 E3 ligases results in less polyubiquitination of DAF-16, and …

… 1 and DAF-16 act in the same pathway, we crossed the daf-16(… longevity by adding
polyubiquitin on DAF-16, leading to its … In the scenario where MALT-1 would cleave RLE-1, this …

… Caenorhabditis elegans ortholog of Regnase-1, we have uncovered its functional relationship
with RLE-1, … the ets-4 decay, RLE-1 could regulate additional mRNAs independently from …