… As a result of RYBP’s ubiquitin binding abilities, RYBP impairs breast cancer gene 1 (BRCA1)
complex recruitment and inhibits homologous recombination repair [2]. RYBP is also …

… RYBP was downregulated in ESCC compared with adjacent normal tissues. A high level of
RYBP … Furthermore, overexpression of RYBP inhibited ESCC growth both in vitro and in vivo. …

… repair systems have evolved. There are two major DSB repair pathways: non-homologous
end joining … The knockdown/knockout or chemical inhibition of FBXW7 increased p53 protein …

… of lytic viral gene expression and subsequent establishment and maintenance of viral latency
… also represses RTA expression, we propose based on these results that RYBP can inhibit …

… RYBP in ncPRC1 also has a role in DNA damage response (DDR) and inhibition of homologous
recombination (HR) repair (Ali et al. … ETS1 binding to the RYBP promoter stimulates its …

… DNA sites repaired by homologous recombination. For these reasons, PARP inhibitors have
… context of inhibited homologous recombination DNA repair mechanisms. So far, four PARP …

… of RYBP protein in the GEMresistant and counterpart cells by inhibiting the de novo protein
… overexpression enhanced homologous recombination (HR)-mediated DNA repair. Indeed, …

… In this study, we used Rybp conditional knockout mouse model to genetically ablate
Rybp in … Additionally, RYBP inhibits DNA double-strand break (DSB) repair in a PRC1-independent …

… RYBP (Ring1 and YY1 binding protein), an … roles of Rybp in neuronal development remains
completely unknown. In the present study, we have shown that the depletion of Rybp inhibits …

… the RYBP 3’-UTR for putative binding sites of miRNAs known to be oncogenic in GBM. We
predicted that inhibition of these miRNAs would increase RYBP mRNA and protein levels, …