Randomized trial of interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction
K Broch, AK Anstensrud, S Woxholt, K Sharma… - Journal of the American …, 2021 - jacc.org
… This study sought to evaluate the effect of the interleukin-6 … In the ASSAIL-MI trial, we
randomized 199 patients with acute ST-… For safety reasons, we excluded patients with a time from …
randomized 199 patients with acute ST-… For safety reasons, we excluded patients with a time from …
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
C Huse, AK Anstensrud, AE Michelsen, T Ueland… - …, 2022 - thelancet.com
… In this predefined exploratory sub-study of the ASSAIL-MI trial we examined the effect of …
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of …
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of …
Interleukin-6 Receptor Inhibition in Acute St-Segment Elevation Myocardial Infarction: A Randomised Placebo-Controlled Trial
K Broch, AK Anstensrud, S Woxholt, K Sharma… - 2021 - papers.ssrn.com
… With the ASSAIL-MI trial, we show that a single dose of tocilizumab significantly increased …
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of …
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of …
Acute ST-elevation Myocardial Infarction and Interleukin-6 Inhibition Cardioprotection and Novel Therapeutic Strategies
AK Anstensrud - 2023 - duo.uio.no
… ASSAIL-MI trial: to describe the rationale and design of the ASSAIL-MI trial, to investigate the
effect … In the ASSAIL-MI trial, our main objective was to assess the effect of IL-6 inhibition in …
effect … In the ASSAIL-MI trial, our main objective was to assess the effect of IL-6 inhibition in …
Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size
KM Kindberg, K Broch, GØ Andersen, AK Anstensrud… - JACC: Advances, 2024 - jacc.org
… The purpose of this study was to evaluate the effect of tocilizumab on … The design of
ASSAIL-MI has been published previously. … In this substudy of the ASSAIL-MI trial, we show that …
ASSAIL-MI has been published previously. … In this substudy of the ASSAIL-MI trial, we show that …
Targeting inflammation after myocardial infarction
… AMI induces a pro-inflammatory state, the primary purpose of which … investigations such as
the ongoing ASSAIL-MI trial [65]. … the anti-inflammatory effects of several immunomodulatory …
the ongoing ASSAIL-MI trial [65]. … the anti-inflammatory effects of several immunomodulatory …
Inflammation in acute myocardial infarction: the good, the bad and the ugly
… and showing their design as well as their … effect for anti-inflammatory therapy than the
STEMI patients included in VCU-ART3. Following the same rationale, the recent ASSAIL-MI trial …
STEMI patients included in VCU-ART3. Following the same rationale, the recent ASSAIL-MI trial …
Efficacy and safety of inhibiting the NLRP3/IL‐1β/IL‐6 pathway in patients with ST‐elevation myocardial infarction: A meta‐analysis
F He, T Xie, D Ni, T Tang… - … Journal of Clinical …, 2023 - Wiley Online Library
… used a random-effects model to assess the pooled treatment effect. … One reason for this
could be that the risk of MI is higher in … In the ASSAIL-MI trial, tocilizumab increased myocardial …
could be that the risk of MI is higher in … In the ASSAIL-MI trial, tocilizumab increased myocardial …
Exploring the Landscape of Anti-Inflammatory Trials: A Comprehensive Review of Strategies for Targeting Inflammation in Acute Myocardial Infraction
A Mitsis, M Kyriakou, S Sokratous, G Karmioti… - Biomedicines, 2024 - mdpi.com
… among patients with acute STEMI in the ASSAIL-MI trial [52]. … larger controlled studies to fully
examine their impact on clinical … For this purpose, the use of the dietary inflammatory index (…
examine their impact on clinical … For this purpose, the use of the dietary inflammatory index (…
Anti-inflammatory therapy for coronary atherosclerotic heart disease: unanswered questions behind existing successes
J Ma, X Chen - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
… For these reasons, researchers moved to IL-6; they found that … Next, researchers designed
a clinical trial to evaluate the effect … ), and this clinical trial is called the ASSAIL-MI trial. The …
a clinical trial to evaluate the effect … ), and this clinical trial is called the ASSAIL-MI trial. The …