Molecular-level examination of amorphous solid dispersion dissolution

MA Faiz Afzal, K Lehmkemper, E Sobich… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule …
(2−5) Such amorphous solid dispersions (ASDs) are a versatile technology for controlling the …

Insights into the release mechanisms of ITZ: HPMCAS amorphous solid dispersions: the role of drug-rich colloids

PD Nunes, JF Pinto, J Henriques… - Molecular …, 2021 - ACS Publications
… (46) Dynamic light scattering is a useful tool to characterize the size of the species present
in the medium upon the dissolution of amorphous solid dispersions, so it was applied in this …

Continuous manufacturing and molecular modeling of pharmaceutical amorphous solid dispersions

AG Nambiar, M Singh, AR Mali, DR Serrano… - AAPS …, 2022 - Springer
… Using ES, micro- and nanometric polymer fibers are created by the generation and …
nano-scale amorphous solid dispersion in electrospun fibers with a large surface area (33). …

High-Drug-Loading Amorphous Solid Dispersions via In Situ Thermal Cross-Linking: Unraveling the Mechanisms of Stabilization

A Kapourani, EG Andriotis, K Chachlioutaki… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) have attracted the interest of several pharmaceutical
formulation scientists due to their unique features and a wide variety of applications. By …

[HTML][HTML] Drug-rich phases induced by amorphous solid dispersion: arbitrary or intentional goal in oral drug delivery?

K Qian, L Stella, DS Jones, GP Andrews, H Du, Y Tian - Pharmaceutics, 2021 - mdpi.com
Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

[HTML][HTML] Recent advances in the application of characterization techniques for studying physical stability of amorphous pharmaceutical solids

Y Wang, Y Wang, J Cheng, H Chen, J Xu, Z Liu, Q Shi… - Crystals, 2021 - mdpi.com
… -state nuclear magnetic resonance (SS-NMR) has also been introduced into the pharmaceutical
field for studying the dynamics and phase composition of amorphous solid dispersions […

The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions

S Dedroog, E Boel, C Kindts, B Appeltans… - International Journal of …, 2021 - Elsevier
… In spite of the fact that spray drying is widely applied for the formulation of amorphous solid
dispersions (ASDs), the influence of the solvent on the physical properties of the ASDs is still …

[HTML][HTML] Amorphous solid dispersions and the contribution of nanoparticles to in vitro dissolution and in vivo testing: Niclosamide as a case study

MO Jara, ZN Warnken, RO Williams III - Pharmaceutics, 2021 - mdpi.com
… This study demonstrates that an amorphous solid dispersion of niclosamide increased
the drug’s bioavailability in a rat model. This model was particularly challenging for the …

Amorphous solid dispersions containing residual crystallinity: competition between dissolution and matrix crystallization

DE Moseson, ID Corum, A Lust, KJ Altman, TN Hiew… - The AAPS journal, 2021 - Springer
… Dissolution testing during development of amorphous solid dispersion products should
be sensitive to variations during product manufacturing or storage that may negatively affect …

Advanced structural characterisation of pharmaceuticals using nano-thermal analysis (nano-TA)

CF Goh, ME Lane - Advanced Drug Delivery Reviews, 2022 - Elsevier
… to characterise micro- and nano-scale heterogeneity and … understanding of the influence
of the subtle microstructural phase separation of lopinavir-HPMC amorphous solid dispersions