Podocyte integrin-β3 and activated protein C coordinately restrict RhoA signaling and ameliorate diabetic nephropathy

T Madhusudhan, S Ghosh, H Wang… - Journal of the …, 2020 - journals.lww.com
… The following inhibitors, agonists, and antagonists were used in this study: RGDS, Cyclo-RGDfv,
human thrombin, … The number of podocytes that migrated into the scratch were counted. …

Neutrophil Protein Kinase R Mediates Endothelial Adhesion and Migration by the Promotion of Neutrophil Actin Polymerization

R Inoue, H Nishi, M Osaka, M Yoshida… - The Journal of …, 2022 - journals.aai.org
… To confirm the PKR inhibition effect on the neutrophil migratory capacity in vivo, we performed
a murine dorsal air pouch model, which is adopted to demonstrate inflammatory leukocyte …

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β2-integrin activation and signaling

H Conley, RL Till, AK Berglund, SL Jones… - … Adhesion & Migration, 2023 - Taylor & Francis
inhibition would alter neutrophil β 2 -integrin activation and signaling. We utilized a
MARCKS-targeting peptide to inhibit … P38 is also involved in neutrophil β 2 -integrin mediated

[HTML][HTML] Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway

K Krotova, N Khodayari, R Oshins, G Aslanidi… - Scientific reports, 2020 - nature.com
activation since it can be inhibited by specific Src inhibitor, … in human Mɸ NE activates integrins
and integrin-mediated … used by Mɸ for adhesion and migration and implicated in different …

Soluble uric acid inhibits β2 integrinmediated neutrophil recruitment in innate immunity

…, M Pruenster, M Sellmayr, C Li… - Blood, The Journal …, 2022 - ashpublications.org
… /recycling in activated human neutrophils, thus impairing their migratory capability in vitro.
This … Studies also reported that integrin-mediated neutrophil activation and migration are …

Nexinhib20 Inhibits Neutrophil Adhesion and β2 Integrin Activation by Antagonizing Rac-1–Guanosine 5′-Triphosphate Interaction

W Liu, CG Cronin, Z Cao, C Wang, J Ruan… - The Journal of …, 2022 - journals.aai.org
… that a neutrophil exocytosis inhibitor Nexinhib20 inhibits not … but also neutrophil adhesion
by limiting β 2 integrin activation. Using … inhibited IL-8–induced β 2 integrin–dependent human

[HTML][HTML] A humanized β2 integrin knockin mouse reveals localized intra-and extravascular neutrophil integrin activation in vivo

L Wen, A Marki, Z Wang, M Orecchioni, J Makings… - Cell reports, 2022 - cell.com
… area at the rear of arresting neutrophils in vivo. In a … activated in association with elevated
neutrophil adhesion in lung and liver. Thus, these mice enable studies of β 2 integrin activation

The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils

…, Z Yuan, K Li, RP McEver, H Lu, C Zhu - Journal of Cell …, 2021 - journals.biologists.com
… β 2 integrin activation is blocked by mitogen-activated protein kinase (MAPK) inhibitors and
… can be converted rapidly from selectin-mediated rolling to integrin-mediated arrest in 80 or …

The Role of G alpha 13 in Integrin-dependent Neutrophil Migration

CWJ Chang - 2021 - search.proquest.com
… The role of Gα13 in neutrophil migration speed and directionality on … does not affect neutrophil
adhesion to ICAM-1, but inhibits the … inhibits motility but not the directionality of neutrophil

[HTML][HTML] β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response

VA Morikis, SJ Chen, J Madigan, MH Jo, LC Werba… - Cells, 2022 - mdpi.com
… of neutrophils in the circulation to a migratory polarized state … bound by allosteric activating
or inhibiting antibodies linked to … of neutrophils to activate integrin mediated binding to …