Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid
C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
… and subcutaneous tissue of obese patients undergoing bariatric surgery, compared with a
… were distinctly lower in the obese group than in the non-obese group, but decreased more …
… were distinctly lower in the obese group than in the non-obese group, but decreased more …
Linezolid concentrations in plasma and subcutaneous tissue are reduced in obese patients, resulting in a higher risk of underdosing in critically ill patients: a …
P Simon, D Busse, D Petroff, C Dorn, L Ehmann… - Journal of Clinical …, 2020 - mdpi.com
… , we accrued obese and non-obese patients undergoing … free linezolid concentrations in
soft tissue by microdialysis. … at a subcutaneous target site, in morbidly obese patients and …
soft tissue by microdialysis. … at a subcutaneous target site, in morbidly obese patients and …
Prophylactic cefazolin dosing in women with body mass index> 35 kg· m− 2 undergoing cesarean delivery: a pharmacokinetic study of plasma and interstitial fluid
VA Eley, R Christensen, R Ryan, D Jackson… - Anesthesia & …, 2020 - journals.lww.com
… We used a reduction of AIC for statistical … of cefazolin after 2 hours may be required to be
certain of achieving target concentrations of >2 mg·L −1 in the ISF of subcutaneous tissue in …
certain of achieving target concentrations of >2 mg·L −1 in the ISF of subcutaneous tissue in …
Prophylactic cefazolin dosing in obesity—a systematic review
M Coates, A Shield, GM Peterson, Z Hussain - Obesity Surgery, 2022 - Springer
… reduce the efficacy of a standard dose for non-obese … in the cohort with obesity compared to
the non-obese cohort, … g doses in plasma and subcutaneous tissue concentrations and used …
the non-obese cohort, … g doses in plasma and subcutaneous tissue concentrations and used …
Application of a physiologically based pharmacokinetic model to predict cefazolin and cefuroxime disposition in obese pregnant women undergoing caesarean …
… lipophilicity of cefuroxime is lower than cefazolin (Log p … cefazolin in non–pregnant, non–obese
subjects as well as in … simulated cefazolin total adipose concentrations in morbidly obese …
subjects as well as in … simulated cefazolin total adipose concentrations in morbidly obese …
[HTML][HTML] Population pharmacokinetics and pharmacodynamics of cefazolin using total and unbound serum concentrations in patients with high body weight
EK Chung, SC Cheatham, DP Healy, AH Stock… - International journal of …, 2023 - Elsevier
… with non-obese patients for various infectious diseases, including skin and soft tissue …
Alternatively, another agent may be preferred to cefazolin for these patients infected by less …
Alternatively, another agent may be preferred to cefazolin for these patients infected by less …
Plasma and interstitial fluid pharmacokinetics of prophylactic cefazolin in elective bariatric surgery patients
RL Ryan, D Jackson, G Hopkins, V Eley… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
… in obese and morbidly obese bariatric surgery patients. … penetration of cefazolin and reduced
probability of achieving … ) were inserted into subcutaneous tissue in an upper quadrant of …
probability of achieving … ) were inserted into subcutaneous tissue in an upper quadrant of …
Ciprofloxacin pharmacokinetics after oral and intravenous administration in (morbidly) obese and non-obese individuals: a prospective clinical study
KP van Rhee, C Smit, RE Wasmann… - Clinical …, 2022 - Springer
… Soft tissue concentrations were predicted to be lower in … both plasma and soft tissue in obese
and non-obese patients under … Cefazolin demonstrated similar behavior, as clearance from …
and non-obese patients under … Cefazolin demonstrated similar behavior, as clearance from …
Morphomics‐informed population pharmacokinetic and physiologically‐based pharmacokinetic modeling to optimize cefazolin surgical prophylaxis
S Liu, A Matvekas, T Naimi, A Ghanem… - … : The Journal of …, 2024 - Wiley Online Library
… More specifically, reduced subcutaneous fat tissue exposure … tissue partitioning of cefazolin
in patients with morbid obesity. … of cefazolin and metronidazole in obese and non-obese …
in patients with morbid obesity. … of cefazolin and metronidazole in obese and non-obese …
Tigecycline soft tissue penetration in obese and non-obese surgical patients determined by using in vivo microdialysis
C Dorn, D Petroff, A Kratzer, F Kees, C Kloft… - European Journal of …, 2022 - Springer
… The results of this study revealed that total plasma concentrations were significantly lower
in obese patients compared to non-obese patients. In contrast, the free plasma concentrations …
in obese patients compared to non-obese patients. In contrast, the free plasma concentrations …