Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid

C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
… and subcutaneous tissue of obese patients undergoing bariatric surgery, compared with a
… were distinctly lower in the obese group than in the non-obese group, but decreased more …

Linezolid concentrations in plasma and subcutaneous tissue are reduced in obese patients, resulting in a higher risk of underdosing in critically ill patients: a …

P Simon, D Busse, D Petroff, C Dorn, L Ehmann… - Journal of Clinical …, 2020 - mdpi.com
… , we accrued obese and non-obese patients undergoing … free linezolid concentrations in
soft tissue by microdialysis. … at a subcutaneous target site, in morbidly obese patients and …

Prophylactic cefazolin dosing in women with body mass index> 35 kg· m− 2 undergoing cesarean delivery: a pharmacokinetic study of plasma and interstitial fluid

VA Eley, R Christensen, R Ryan, D Jackson… - Anesthesia & …, 2020 - journals.lww.com
… We used a reduction of AIC for statistical … of cefazolin after 2 hours may be required to be
certain of achieving target concentrations of >2 mg·L −1 in the ISF of subcutaneous tissue in …

Prophylactic cefazolin dosing in obesity—a systematic review

M Coates, A Shield, GM Peterson, Z Hussain - Obesity Surgery, 2022 - Springer
reduce the efficacy of a standard dose for non-obese … in the cohort with obesity compared to
the non-obese cohort, … g doses in plasma and subcutaneous tissue concentrations and used …

Application of a physiologically based pharmacokinetic model to predict cefazolin and cefuroxime disposition in obese pregnant women undergoing caesarean …

HH Alrammaal, K Abduljalil, V Hodgetts Morton… - Pharmaceutics, 2022 - mdpi.com
… lipophilicity of cefuroxime is lower than cefazolin (Log p … cefazolin in non–pregnant, nonobese
subjects as well as in … simulated cefazolin total adipose concentrations in morbidly obese

[HTML][HTML] Population pharmacokinetics and pharmacodynamics of cefazolin using total and unbound serum concentrations in patients with high body weight

EK Chung, SC Cheatham, DP Healy, AH Stock… - International journal of …, 2023 - Elsevier
… with non-obese patients for various infectious diseases, including skin and soft tissue
Alternatively, another agent may be preferred to cefazolin for these patients infected by less

Plasma and interstitial fluid pharmacokinetics of prophylactic cefazolin in elective bariatric surgery patients

RL Ryan, D Jackson, G Hopkins, V Eley… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
… in obese and morbidly obese bariatric surgery patients. … penetration of cefazolin and reduced
probability of achieving … ) were inserted into subcutaneous tissue in an upper quadrant of …

Ciprofloxacin pharmacokinetics after oral and intravenous administration in (morbidly) obese and non-obese individuals: a prospective clinical study

KP van Rhee, C Smit, RE Wasmann… - Clinical …, 2022 - Springer
Soft tissue concentrations were predicted to be lower in … both plasma and soft tissue in obese
and non-obese patients under … Cefazolin demonstrated similar behavior, as clearance from …

Morphomics‐informed population pharmacokinetic and physiologically‐based pharmacokinetic modeling to optimize cefazolin surgical prophylaxis

S Liu, A Matvekas, T Naimi, A Ghanem… - … : The Journal of …, 2024 - Wiley Online Library
… More specifically, reduced subcutaneous fat tissue exposure … tissue partitioning of cefazolin
in patients with morbid obesity. … of cefazolin and metronidazole in obese and non-obese

Tigecycline soft tissue penetration in obese and non-obese surgical patients determined by using in vivo microdialysis

C Dorn, D Petroff, A Kratzer, F Kees, C Kloft… - European Journal of …, 2022 - Springer
… The results of this study revealed that total plasma concentrations were significantly lower
in obese patients compared to non-obese patients. In contrast, the free plasma concentrations …