Dynamic regulation of B cell complement signaling is integral to germinal center responses
… Activated GL7 + Fas + B cells at the interface between the B cell follicle and the T … This
surface phenotype therefore precedes key cell fate transitions in mature B cells. Persistence of …
surface phenotype therefore precedes key cell fate transitions in mature B cells. Persistence of …
Homeostasis and regulation of autoreactive B cells
… to positively select follicular (FO) B cells. The autoreactivity of … during B-cell development,
even for FO B cells, and B cells … choice of transitional B cells between FO B and MZ B cells is …
even for FO B cells, and B cells … choice of transitional B cells between FO B and MZ B cells is …
Distinct metabolic requirements regulate B cell activation and germinal center responses
R Sharma, RM Smolkin, P Chowdhury… - Nature …, 2023 - nature.com
… B cells migrates into B cell follicles where they interact with cognate CD4 + follicular helper
T (T FH ) cells, … requirements of B cells during their transitions from naïve to activated states. …
T (T FH ) cells, … requirements of B cells during their transitions from naïve to activated states. …
Unraveling the mysteries of plasma cells
… transcriptional profile and the transition from a proliferating (ie… plasma cells are mostly
generated outside of B cell follicles … B cells from these mice failed to differentiate into plasma cells…
generated outside of B cell follicles … B cells from these mice failed to differentiate into plasma cells…
Regulation of B cell responses in sle by three classes of interferons
PP Domeier, ZSM Rahman - International journal of molecular sciences, 2021 - mdpi.com
… Transitional B cells are subdivided into transitional type 1 (T1), … Mature B cells develop from
transitional cells and are … to B cell follicles and promote autoimmune B cell responses and …
transitional cells and are … to B cell follicles and promote autoimmune B cell responses and …
Notch2-mediated plasticity between marginal zone and follicular B cells
M Lechner, T Engleitner, T Babushku… - Nature …, 2021 - nature.com
… is induced within the follicular B cell zone. Since the … of transitional B cells, we inhibited the
influx of immature B cells … Expectably, unlike CD19-proficient control B cells, purified B cells …
influx of immature B cells … Expectably, unlike CD19-proficient control B cells, purified B cells …
[HTML][HTML] IL-17–producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice
… or IL-21 into the coculture of B cells and Tfh cells from control mice. Exogenous cytokines
increased activation of B cells in cultures of B cells alone, but not in B cells with Tfh cells. IL-17 …
increased activation of B cells in cultures of B cells alone, but not in B cells with Tfh cells. IL-17 …
Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing
X Li, L Gong, AP Meli, D Karo-Atar, W Sun… - Journal of Experimental …, 2020 - rupress.org
… B cells depend on Cbl and Cbl-b (Cbls), which consequently control naive B and cognate T
follicular helper (Tfh) cell … 339 peptide at day 4 so it could be loaded into MHC-II of the B cells …
follicular helper (Tfh) cell … 339 peptide at day 4 so it could be loaded into MHC-II of the B cells …
Plasma cell fate is orchestrated by elaborate changes in genome compartmentalization and inter-chromosomal hubs
… B cells, which further differentiate into germinal center B cells or extra-follicular antibody-secreting
plasma cells (… This analysis revealed that, during the naive to plasma cell transition, …
plasma cells (… This analysis revealed that, during the naive to plasma cell transition, …
[HTML][HTML] An integrated multi-omic single-cell atlas of human B cell identity
… The conserved molecules were selected to facilitate gating into four canonical B cell
subsets: transitional, naive, non-switched memory, and switched memory (Figures S1A and 1…
subsets: transitional, naive, non-switched memory, and switched memory (Figures S1A and 1…