… also shown to be beneficial in reducing atherosclerotic lesions … with insulin resistance, as
the prevention of C18-ceramide … improved glucose homeostasis and insulin sensitivity in high-…

… of ceramides with distinct acyl chain lengths can regulate … ceramidase activity might contribute
to the beneficial metabolic … of energy and glucose homeostasis remain elusive 53 . Thus, …

… a variety of ceramide species differing in acyl chain length and … of both glucose homeostasis
and mitochondrial fitness … will be especially beneficial for the identification of all ceramide-…

… acyl-chain is an important determinant of ceramide function, such that a small subset of
ceramides (eg, those containing the C16 or C18 acyl-chain) alter metabolism by inhibiting insulin …

… sphingolipid levels could be useful in enabling clinicians to … ceramide, suggesting that
the altered sphingolipid acyl chain … resistance development and glucose homeostasis …

… involved in the regulation of ceramides and S1P association … ) into ceramide species with
different fatty acid chain lengths [… for a beneficial role of apoM/S1P complex in the regulation of …

… affect the acyl-chain composition of cellular ceramides, hence … useful pharmacological
reagents for investigating ceramide … insulin resistance and dysregulation of glucose homeostasis […

… different acyl chain lengths [50]. Finally, dihydroceramides are converted into ceramides by
… Decreasing ceramide content in AT triggered beneficial effects in the liver. However, this …

… understand the acyl chain length specificity of ceramide-mediated … of ceramidase activity
leads to beneficial metabolic … to adjust lipid and glucose homeostasis (this theory is discussed …

… Ceramides can also acquire another acyl chain at this first … across multiple studies and
strains as good markers of diet-induced … improves glucose homeostasis by enhancing insulin …