Hypoxia-inducible factor 1 and mitochondria: an intimate connection

X Huang, L Zhao, R Peng - Biomolecules, 2022 - mdpi.com
… , which contributed to hypoxic signaling via HIF activation and was regulated by cross-talk …
contributed to hypoxic signaling via HIF activation, and was regulated through cross-talk …

Mitochondrial regulation of the hypoxia-inducible factor in the development of pulmonary hypertension

EM Zeidan, MA Hossain, M El-Daly… - Journal of Clinical …, 2022 - mdpi.com
… of hypoxia-induced PH, possibly via stabilization of the hypoxia-inducible factor-1 (HIF1), the
… Thus, this review focuses on mitochondrial regulation of HIF1α signaling in chronic hypoxia-…

[HTML][HTML] Licochalcone A inhibits hypoxia-inducible factor-accumulation by suppressing mitochondrial respiration in hypoxic cancer cells

MK Park, J Ji, K Haam, TH Han, S Lim, MJ Kang… - Biomedicine & …, 2021 - Elsevier
… 1α accumulation via post-transcriptional regulation, resulting … nitric oxide production by
suppressing inducible nitric oxide … A induces mitochondria-dependent apoptosis by generating …

Stemness of human pluripotent cells: Hypoxia-like response induced by low nitric oxide

E Caballano-Infantes, I Díaz, AB Hitos, GM Cahuana… - Antioxidants, 2021 - mdpi.com
… for mitochondrial dynamics during cell reprogramming and … response orchestrated by
hypoxia-inducible factors (HIFs 1–3)… gas messenger nitric oxide (NO) has been reported to …

[HTML][HTML] Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and-independent actions on macrophages

D Drehmer, JPM Luiz, CAS Hernandez, JC Alves-Filho… - Redox biology, 2022 - Elsevier
… Furthermore, we found that NO, through mitochondria-dependent and -independent …
substitute for negative control. Whole sections were then scanned using an Olympus VS120 slide …

Hypoxia-inducible factor-1: Regulatory mechanisms and drug therapy in myocardial infarction

J Pan, L Zhang, D Li, Y Li, M Lu, Y Hu, B Sun… - European journal of …, 2023 - Elsevier
… to acute ischemia and hypoxia through various mechanisms. … This study aimed to summarize
the regulatory role of HIF-1 in … of the M1 marker gene inducible nitric oxide synthase and the …

[HTML][HTML] Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a …

J Shi, T Yu, K Song, S Du, S He, X Hu, X Li, H Li… - Redox biology, 2021 - Elsevier
mitochondria-dependent apoptosis [10,11]. Recently, it has been found that DEX was endowed
with regulationHypoxia inducible factor- (HIF-1α), the major functional subunit of HIF-1…

Activation of transcription factor HIF inhibits IL-1β-induced NO production in primary cultured rat hepatocytes

T Yoshida, T Okumura, Y Matsuo, T Okuyama… - Nitric Oxide, 2022 - Elsevier
… activity through the NF-κB pathway to produce nitric oxide (NO… We hypothesized that applying
hypoxia-inducible factor-prolyl … against the elongation factor- used as an internal control. …

The role of hypoxia-inducible factor-1 alpha in renal disease

H Liu, Y Li, J Xiong - Molecules, 2022 - mdpi.com
mitochondria-dependent apoptosis in the tubular cells of DN … plays an important regulatory
role in DN through miR-34a-5p/… HIF-1α can activate inducible nitric oxide synthase (iNOS) …

Caveolin-1-mediated tumor suppression is linked to reduced HIF1α S-Nitrosylation and transcriptional activity in hypoxia

C Sanhueza, JC Bennett, M Valenzuela-Valderrama… - Cancers, 2020 - mdpi.com
… of the hypoxia-inducible factor- (HIF1α) promotes tumor growth. HIF1α is regulated by …
Some of the best-characterized CAV1 target proteins to date are the nitric oxide synthases (…