Limitations of animal studies for predicting toxicity in clinical trials: Part 2: Potential alternatives to the use of animals in preclinical trials

GA Van Norman - Basic to Translational Science, 2020 - jacc.org
… submitting in silico data in support of regulatory advancement of … no regulatory submissions
are in question, than for toxicity … in clinical trials: is it time to rethink our current approach?"J …

A socio-environmental perspective on pesticide use and food production

HO Gomes, JMC Menezes, JGM da Costa… - Ecotoxicology and …, 2020 - Elsevier
… For example, in Table 1, some data can be found on the limits allowed for pesticides in … a
new regulatory framework for the classification of toxicity in relation to the use of pesticides. The …

Freshwater sediment quality criteria: toxicity bioassessment

JP Giesy, RA Hoke - Sediments, 2020 - taylorfrancis.com
… reasons we do not advocate the use of the BC approach. … toxicity as the causative factor, and
presence-absence data are … The use of standard protocols has greater regulatory and legal …

The Tox21 10K compound library: collaborative chemistry advancing toxicology

AM Richard, R Huang, S Waidyanatha… - Chemical Research …, 2020 - ACS Publications
… basis of toxicity across research and regulatory domains. Each … of environmental chemicals
lacking toxicity data and, … concern from both exposure and toxicity perspectives. The study …

Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions

L Zimmermann, Z Bartosova, K Braun… - … science & technology, 2021 - ACS Publications
… In brief, we imported the raw data files of PBs (six for the migrates … products is a more
appropriate approach to cover all plastic … regulatory gaps, the combination of whole migrate …

Assessing health and environmental impacts of solvents for producing perovskite solar cells

R Vidal, JA Alberola-Borràs, SN Habisreutinger… - Nature …, 2021 - nature.com
… , we use the ‘USEtox’ method but also consider toxicity data … for perovskite PV and an
approach to compare the human … to ECHA under REACH regulation. Previously, REACH was …

Artificial intelligence and machine learning empower advanced biomedical material design to toxicity prediction

AV Singh, D Rosenkranz, MHD Ansari… - Advanced Intelligent …, 2020 - Wiley Online Library
statistical approach to combine the data derived from a systematic review for a meta-analysis
of different classes of nanomaterials and their example application … to regulatory experts in …

Stereoselective toxicity mechanism of neonicotinoid dinotefuran in honeybees: New perspective from a spatial metabolomics study

Y Zhang, D Chen, Y Xu, L Ma, M Du, P Li, Z Yin… - Science of the Total …, 2022 - Elsevier
toxicity is key to preventing global population declines of honeybees, whereas little is known
about the in situ metabolic regulationused MetaboAnalyst 4.0 software to test the statistical

Per‐and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research

SE Fenton, A Ducatman, A Boobis… - Environmental …, 2021 - Wiley Online Library
… PFAS in commerce lacking toxicity data, more contemporary … the development of toxicity
information on emerging and … how best to approach studying, grouping, and regulating the …

Revealing adverse outcome pathways from public high-throughput screening data to evaluate new toxicants by a knowledge-based deep neural network approach

HL Ciallella, DP Russo, LM Aleksunes… - … science & technology, 2021 - ACS Publications
… the practical applications of the approach for other complex toxicitydata and computational
methods to pave the way for the regulatory acceptance of non-animal methods in toxicity