Limitations of animal studies for predicting toxicity in clinical trials: Part 2: Potential alternatives to the use of animals in preclinical trials
GA Van Norman - Basic to Translational Science, 2020 - jacc.org
… submitting in silico data in support of regulatory advancement of … no regulatory submissions
are in question, than for toxicity … in clinical trials: is it time to rethink our current approach?"J …
are in question, than for toxicity … in clinical trials: is it time to rethink our current approach?"J …
A socio-environmental perspective on pesticide use and food production
HO Gomes, JMC Menezes, JGM da Costa… - Ecotoxicology and …, 2020 - Elsevier
… For example, in Table 1, some data can be found on the limits allowed for pesticides in … a
new regulatory framework for the classification of toxicity in relation to the use of pesticides. The …
new regulatory framework for the classification of toxicity in relation to the use of pesticides. The …
Freshwater sediment quality criteria: toxicity bioassessment
… reasons we do not advocate the use of the BC approach. … toxicity as the causative factor, and
presence-absence data are … The use of standard protocols has greater regulatory and legal …
presence-absence data are … The use of standard protocols has greater regulatory and legal …
The Tox21 10K compound library: collaborative chemistry advancing toxicology
AM Richard, R Huang, S Waidyanatha… - Chemical Research …, 2020 - ACS Publications
… basis of toxicity across research and regulatory domains. Each … of environmental chemicals
lacking toxicity data and, … concern from both exposure and toxicity perspectives. The study …
lacking toxicity data and, … concern from both exposure and toxicity perspectives. The study …
Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions
L Zimmermann, Z Bartosova, K Braun… - … science & technology, 2021 - ACS Publications
… In brief, we imported the raw data files of PBs (six for the migrates … products is a more
appropriate approach to cover all plastic … regulatory gaps, the combination of whole migrate …
appropriate approach to cover all plastic … regulatory gaps, the combination of whole migrate …
Assessing health and environmental impacts of solvents for producing perovskite solar cells
… , we use the ‘USEtox’ method but also consider toxicity data … for perovskite PV and an
approach to compare the human … to ECHA under REACH regulation. Previously, REACH was …
approach to compare the human … to ECHA under REACH regulation. Previously, REACH was …
Artificial intelligence and machine learning empower advanced biomedical material design to toxicity prediction
AV Singh, D Rosenkranz, MHD Ansari… - Advanced Intelligent …, 2020 - Wiley Online Library
… statistical approach to combine the data derived from a systematic review for a meta-analysis
of different classes of nanomaterials and their example application … to regulatory experts in …
of different classes of nanomaterials and their example application … to regulatory experts in …
Stereoselective toxicity mechanism of neonicotinoid dinotefuran in honeybees: New perspective from a spatial metabolomics study
Y Zhang, D Chen, Y Xu, L Ma, M Du, P Li, Z Yin… - Science of the Total …, 2022 - Elsevier
… toxicity is key to preventing global population declines of honeybees, whereas little is known
about the in situ metabolic regulation … used MetaboAnalyst 4.0 software to test the statistical …
about the in situ metabolic regulation … used MetaboAnalyst 4.0 software to test the statistical …
Per‐and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research
… PFAS in commerce lacking toxicity data, more contemporary … the development of toxicity
information on emerging and … how best to approach studying, grouping, and regulating the …
information on emerging and … how best to approach studying, grouping, and regulating the …
Revealing adverse outcome pathways from public high-throughput screening data to evaluate new toxicants by a knowledge-based deep neural network approach
… the practical applications of the approach for other complex toxicity … data and computational
methods to pave the way for the regulatory acceptance of non-animal methods in toxicity …
methods to pave the way for the regulatory acceptance of non-animal methods in toxicity …