… Introns that are removed via splicing have a lasso shape and … AU-rich element (ARE)-mediated
decay (AMD). AREs are … are known for rapid degradation of the c-fos mRNA in the cell; …

… tion of mRNA destabilization elements, such as m6A, AU-rich … To interfere with global mRNA
degradation, we expressed a … in neuritic translation and a subsequent decrease in neuronal …

… in their 3ʹ UTRs such as AU-rich elements (ARE) or … to ~60 minutes for unstable
mRNAs such as c-Fos and the β-… Deletion of the proposed PAM2 sequence or mutation of …

… mRNA from degradation. Changes in translation initiation rewire the translation process to
facilitate … In the subsequent sections, we will show how they trigger downstream effects that …

… the pellet was air dried to remove residual acetone from the … transcript underwent steady
degradation in both WT and KO … related AU rich element (ARE) containing mRNAs, such as c-fos…

… sequences and structures in 3′UTRs, such as AU-rich … the degradation machinery to
ARE-containing mRNAs. For … In addition, mRNAs encoding prosurvival proteins such as FOS (c-fos…

… AU-rich elements (AREs) [20], the ability to (re)-elongate the … blot is due to poly(A) lengthening,
removal of poly(A) by oligo(… For example, CPEB4-activated c-Fos translation occurs only …

… FIG 3 AB-452 promotes HBV RNA degradation through … and poly(A) tail integrity, knockout
(KO) cell lines with deletion of … sequence facilitates the addition of G while extending the …

… Smaug also induces nos mRNA degradation during the first … The NOT10 sequence was
removed from its vector with KpnI … on the substrate, PABPC facilitates further deadenylation. …

… factors preventing or facilitating access of RNases to the 3'-UTR… It seems likely that the effects
of AU-rich sequences on mRNA … ) Removal of poly(A) and consequent degradation of c-fos …