[HTML][HTML] Poly (A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells

FW Zhang, XW Xie, MH Chen, J Tong… - World Journal of …, 2023 - ncbi.nlm.nih.gov
… the poly(A) tail of mRNA transcripts is removed by 3’ to 5’ exonucleases (deadenylases), and
this process is referred to as the rate-limiting step of mRNA degradationSubsequent wound …

Diverse functions of deadenylases in DNA damage response and genomic integrity

YB Yan - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
… pathway and tumor suppressor mRNAs such as c-fos, c-myc, … AU-rich element (ARE) is one
of the most widespread mRNA … biogenesis by removing the genome-encoded 3extensions or …

The m6A-epitranscriptome in brain plasticity, learning and memory

J Widagdo, JJL Wong, V Anggono - Seminars in Cell & Developmental …, 2022 - Elsevier
… the poly-A tail (deadenylation) and subsequent removal of the 5’-cap structure (decapping),
which then triggers the ribonuclease-dependent RNA degradation … by two AU-rich elements (…

Form and function of Poly (A) tails

TJ Eisen - 2020 - dspace.mit.edu
… After export into the cytoplasm, the poly(A) tail is removed by the … mRNA decay rate centered
on AU-rich elements, found in the 3′ UTR and coding sequence of c-fos and other mRNAs (…

[图书][B] The HuR/YB1 Complex Stabilizes Pro-myogenic mRNAs by Interacting with a Consensus U-rich Motif in the 3'UTR

S Busque - 2022 - search.proquest.com
… required for the extraction of the sequence of the 3’UTRs for … vulnerable to 5’ to 3degradation
by the exonuclease Xrn1.… the HuR mRNA by binding to an AU-rich element in its 3’UTR.In …

K-homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders

Q Hassan, J Leavenworth, N Yusuf - Critical Reviews™ in Eukaryotic … - dl.begellhouse.com
… is targeted for decay, whereas the removal of a functional ARE … stretch of an AU-rich
sequence.A second cytoplasmic motif, “… U-rich sequence in the 3' untranslated region of c-fos

[HTML][HTML] Advantages of using paclitaxel in combination with oncolytic adenovirus utilizing RNA destabilization mechanism

E Hossain, U Habiba, A Yanagawa-Matsuda, A Alam… - Cancers, 2020 - mdpi.com
AU-rich elements (ARE) in the 3’-untranslated region (3′-… in cancer cells and thus facilitates
mRNA stabilization [27]. Some … The c-fos ARE causes rapid degradation of E1A mRNA in …

The isolated La-module of LARP1 mediates 3'poly (A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1

S Mattijssen, G Kozlov, S Gaidamakov, A Ranjan… - RNA biology, 2021 - Taylor & Francis
… in their 3ʹ UTRs such as AU-rich elements (ARE) or … to ~60 minutes for unstable
mRNAs such as c-Fos and the β-… Deletion of the proposed PAM2 sequence or mutation of …

Generation of 3′ UTR knockout cell lines by CRISPR/Cas9-mediated genome editing

S Mitschka, MM Fansler, C Mayr - Methods in enzymology, 2021 - Elsevier
… is the Fos mRNA, whose AU-rich elements located in the 3′… found that degradation
rates of long and short 3′UTR mRNA … project aiming to delete a 3′UTR or to influence 3′UTR …

Heat stress induced arginylation of HuR promotes alternative polyadenylation of Hsp70.3 by regulating HuR stability and RNA binding

K Deka, S Saha - Cell Death & Differentiation, 2021 - nature.com
… the pellet was air dried to remove residual acetone from the … transcript underwent steady
degradation in both WT and KO … related AU rich element (ARE) containing mRNAs, such as c-fos