Cumulative effects of weakly repressive regulatory regions in the 3'UTR maintain PD-1 expression homeostasis in mammals

X Lai, R Li, P Wang, M Li, C Xiao, Q Cao, X Li… - Communications …, 2023 - nature.com
… the AU-rich element (ARE) which was first found in the c-fos 3’ … PD-1 elevation due to removal
of the 3’ UTR could potentially … the degradation and silencing of mRNA 40 ; FMR1 binds 3’ …

Investigating the effect of translation inhibition on cellular mRNA levels

M Haque - 2021 - escholarship.mcgill.ca
… guanylyl-transferase activities that remove the γ-phosphate of … harboring AU rich sequences
and the other in the C terminal … N=3 ±SEM (e) The half-lives of c-fos, c-jun and Mcl-1 mRNAs

Post-transcriptional Controls in Nociceptive Signaling

NP Kunder - 2022 - utd-ir.tdl.org
… We focused on two immediate early genes, Arc and c-Fos that … Removal of the 5ˊ- cap
by decapping enzymes or … protein also binds to AU-rich sequences and regulate Poly(A) tail …

Regulation of fetal genes by transitions among RNA-binding proteins during liver development

T Suzuki, S Adachi, C Kikuguchi, S Shibata… - International journal of …, 2020 - mdpi.com
… repression, mRNAs usually undergo degradation in a manner … In contrast, BRF1/2 and
AU-rich element RNA binding factor 1 (… This facilitates studies examining whether a change in …

Downregulation of CPSF6 leads to global mRNA 3'UTR shortening and enhanced antiviral immune responses

Y Ge, J Huang, R Chen, Y Fu, T Ling, X Ou… - Plos …, 2024 - journals.plos.org
… (miRNA) response elements, AU-rich elements (AREs), GU-… mediate degradation or
translational efficiency of mRNAs [10]… CRISPR/Cas9 genome editing to delete the third exon of …

Post-transcriptional gene regulatory networks in chronic airway inflammation: role of RNA-binding proteins

L Ricciardi - 2020 - elea.unisa.it
… through the excision of the loop and subsequent maturation … AU-rich sequences in mRNAs.
This is due to the combination … -2 (COX-2), TNF-α and c-fos, and act through a competitive …

Advances in nanoparticle mediated targeting of RNA binding protein for cancer

R Kashikar, AK Kotha, S Shah, P Famta… - Advanced Drug Delivery …, 2022 - Elsevier
poly (A) tail dedenylation, 5′end m7G cap removal (decapping), 5′→ 3′exonuclease
degradation, and exosome-mediated 3… the regulation of c-Fos, c-Myc, Pten, Rac1, and vimentin …

Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization

FA Krapacher, D Fernández‐Suárez… - The EMBO …, 2022 - embopress.org
… ΔFosB mRNA is generated by the removal of intron 4 (also … Expression of FosB and c-Fos
mRNAs returned to basal levels 24 h … (MOR) mRNA via interaction with AU-rich element RNA-…

[图书][B] Molecular endocrinology: genetic analysis of hormones and their receptors

G Rumsby, S Farrow - 2020 - books.google.com
… ride (LPS), an effect abolished by removal of AU-rich motifs within the 3′-UTR. The … Removal
of poly(A) and consequent degradation of c-fos mRNA facilitated by 3AU-rich sequences

Targeting the “undruggable”: rNA-binding proteins in the spotlight in cancer therapy

C Mir, Y Garcia-Mayea, ME Lleonart - Seminars in Cancer Biology, 2022 - Elsevier
… In contrast, AU-rich binding factor 1 (AUF1), also called … Interestingly, the increased expression
of c-Jun and c-Fos … On the other hand, the removal of mRNA N6-methyladenosine (m 6 A) …