Oncolytic Adenovirus Utilizing RNA Stabilization Mechanism Can Synergize with Chemotherapy

E HOSSAIN - 2020 - eprints.lib.hokudai.ac.jp
… Oncolytic adenovirus can be engineered by the deletion of … for rapid degradation of mRNA
and the fate of AREmRNA is … c-fos AU-rich elements (ARE) in the 3'-untranslated region (3'-…

MicroRNA-Mediated Migration of Colon Cancer Cells

A Algaber - 2021 - portal.research.lu.se
… details, and we will remove access to the work immediately … -5p at AU rich element region
in 3ʹ-UTR of HuR mRNA. In … , including those that can be found in c-fos mRNA. (ii) Class II …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
… Their activity ranges from directing primary mRNA maturation and trafficking to modulation
of transcript stability and/or translation. Accumulating evidence has shown that RBPs are …

HnRNP Pathologies in Frontotemporal Lobar Degeneration

X Jiang, A Gatt, T Lashley - Cells, 2023 - mdpi.com
… The function of hnRNP D is mainly related to RNA degradation. It can interact with AU-rich
In contrast, the deletion of all three KH domains results in an increase in their cytoplasmic …

ELAV-Mediated mRNA Transport in Memory Formation

AA Mirisis - 2023 - search.proquest.com
… of the defensive tail-elicited siphon withdrawal reflex (T-SWR) … c-Jun can associate with the
transcription factor, c-Fos, to form … AU-rich elements (AREs) are found in the 3' UTR of many …

Strength in diversity: nuclear export of viral RNAs

JP Gales, J Kubina, A Geldreich, M Dimitrova - Viruses, 2020 - mdpi.com
… The second major step in mRNA processing is the removal … their degradation via the nuclear
RNA degradation pathway (… is further linked to an AU-rich late negative regulatory element (…

[PDF][PDF] mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons

I Loedige, A Baranovskii, S Mendonsa, S Dantsuji… - Molecular Cell, 2023 - cell.com
… tion of mRNA destabilization elements, such as m6A, AU-rich … To interfere with global mRNA
degradation, we expressed a … in neuritic translation and a subsequent decrease in neuronal …

A SHIFT IN RNA FATE: INVESTIGATING THE ROLE OF C19ORF66 DURING KSHV LYTIC REPLICATION

W Rodriguez Jr - 2023 - scholarworks.umass.edu
… ”, it is removed from the pool of viable mRNAs and will be … a correlation between AU-Rich
elements in each mRNA and its … a cluster of 75 host mRNAs that escape degradation from four …

Hu antigen R (HuR) protein structure, function and regulation in hepatobiliary tumors

S Lachiondo-Ortega, TC Delgado, B Baños-Jaime… - Cancers, 2022 - mdpi.com
… RRMs to AU-rich elements (AREs), typically present in the 3′-… , thus, preventing mRNA
degradation and deadenylation. To … Moreover, deletion of RRM3 critically impaired the ability of …

The Kinetics of RNA Flow Across Subcellular Compartments

BM Smalec - 2022 - search.proquest.com
… -mRNA downstream of the poly(A) signal, and the resulting 3’ … nuclear degradation, as several
pathways that shuttle mRNAs to … AU-rich elements (AREs) are most commonly found in 3’ …