… multiple developmental decisions during embryogenesis. Excess RA induces head … early
events leading to head formation in Xenopus embryos. This effect was mapped to the earliest …

… With 28 these tools in hand, coupled with the insights gleaned from developmental biology
… recapitulate early developmental steps enabling the generation of populations enriched in …

… Retinoic acid (RA) is a central regulatory signal that controls numerous developmental …
Although activation of Hox expression is considered one of the earliest functions of RA signaling …

… upon the graft of an early Hensen's node ectopically, an assay … 9 hr – they only become
enriched for methylation at 12 hr. … developmentally regulated genes is likely to be controlled by …

… of this chapter to describe this early morphogenetic events. … anterior end (rostral), Hensen’s
node, has been well studied … are sensitive to retinoic acid since they contain a retinoic acid-…

… least two steps: the first lasts for 1-2 h of direct contact with the inducing Hensen’s node graft;
a contact … Hensen’s node graft induces mitotic activity in the competent ectoblast in contact. …

… FGF18 and FGF8 are expressed in Hensen’s node and coordinate the progression and …
regulated at HH20 were enriched with the GO of sex differentiation. HH20 corresponds to the first …

… , presomitic mesoderm; RA, retinoic acid; RAR, retinoic acid receptor; RBPJ, recombination
… This ventral enrichment of notch1 mRNA and protein is the earliest localized sign of ventral …

… In this study, we provide the first systematic study of competence in the context of neural …
As described elsewhere in this Thesis, a graft of Hensen’s node into the inner third of the area …

… of knockouts in reporter mESC lines, we identified retinoic acid (RA) as a critical mediator of
… This result based on mouse genetics seemed at first glance in contradiction with our finding …