[HTML][HTML] Neuron loss in Alzheimer's disease: translation in transgenic mouse models
… Alzheimer’s disease (AD) is a neurodegenerative disorder … cholinergic nerve terminals was
evident in 4-month-old homozygous PDAPP mice, no difference in the number of cholinergic …
evident in 4-month-old homozygous PDAPP mice, no difference in the number of cholinergic …
[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis
… Alzheimer’s disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic - the causes of which have not yet been fully …
Two major forms of the disease exist: sporadic - the causes of which have not yet been fully …
[HTML][HTML] Where dopaminergic and cholinergic systems interact: a gateway for tuning neurodegenerative disorders
…, I Sotiropoulos, JM Silva, N Sousa, S Ztaou… - Frontiers in behavioral …, 2021 - frontiersin.org
… changes while drugs that boosting cholinergic system (eg, by AChE … cholinergic hypothesis
has been implicated in the AD etiology and it is based on the degeneration of cholinergic …
has been implicated in the AD etiology and it is based on the degeneration of cholinergic …
PET imaging of cholinergic neurotransmission in neurodegenerative disorders
… The development and successful clinical translation of 18FFEOBV was a breakthrough for …
revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease…
revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease…
[HTML][HTML] A new hypothesis for Alzheimer's disease: The lipid invasion model
JDA Rudge - Journal of Alzheimer's Disease Reports, 2022 - content.iospress.com
… proposes a new hypothesis for Alzheimer’s disease (… cholinergic hypothesis, which emerged
in the 1980s, sought to explain the disease in terms of reduced synthesis of acetylcholine …
in the 1980s, sought to explain the disease in terms of reduced synthesis of acetylcholine …
Addressing the Discrepancies Between Animal Models and Human Alzheimer's Disease Pathology: Implications for Translational Research
… translation of findings. This article analyzes the discrepancies between animal models and
human AD pathology that complicate the translation of … to propose a new perspective on this …
human AD pathology that complicate the translation of … to propose a new perspective on this …
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons
M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
… Emerging evidence highlights a critical role for microglia in … of Alzheimer's Disease, the
cholinergic hypothesis remains both a … in understanding AD, the translation of this knowledge into …
cholinergic hypothesis remains both a … in understanding AD, the translation of this knowledge into …
The search for novel targets in Alzheimer's disease—The 90s redux
C Behl - Progress in Molecular Biology and Translational …, 2021 - Elsevier
… This includes looking back, reactivating, and revisiting findings … data, the translation of the
amyloid cascade hypothesis into … In the early 1980s, the “Cholinergic Hypothesis of AD” was …
amyloid cascade hypothesis into … In the early 1980s, the “Cholinergic Hypothesis of AD” was …
[HTML][HTML] Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: nexus of cholinergic and nerve growth factor dysfunction
DE Moss, RG Perez - Current Alzheimer research, 2021 - ncbi.nlm.nih.gov
… anticholinergics, within a framework of the cholinergic hypothesis of AD and AD-associated …
of trophic factor hypothesis of AD”, we propose that AChE inhibitors enhance acetylcholine-…
of trophic factor hypothesis of AD”, we propose that AChE inhibitors enhance acetylcholine-…
[HTML][HTML] The role of nicotinic cholinergic neurotransmission in delusional thinking
M Caton, ELM Ochoa, FJ Barrantes - NPJ schizophrenia, 2020 - nature.com
… New evidence suggests that the cholinergic system may be implicated not only in cognitive
deficits but also in the development of psychotic symptoms in this patient population 10,101,…
deficits but also in the development of psychotic symptoms in this patient population 10,101,…