Infection and thrombosis are the two major complications in almost any indwelling intravascular catheters, leading to adverse consequences. Here, we report a robust and antiswelling hollow hydrogel tube that is prepared by copolymerizing a hydrogen-bonding (H-bonding) monomer and a zinc methacrylate (ZMA) monomer in the absence of any chemical cross-linker. The strong H-bonding interactions from the side chain of N-acryloylsemicarbazide (NASC) endow the hydrogel with high mechanical strength and swelling stability. Introduction of ZMA affords a superhydrophilic surface, and the release of a zinc ion (Zn²⁺) from the hydrogel can kill nearly 100% both of Staphylococcus aureus and Escherichia coli, indicating its excellent antibacterial ability. Importantly, the P(NASC-co-ZMA) hydrogel exhibits better antithrombosis ability due to the resistant adhesion of fibrinogen protein and platelets, as well binding calcium ions (Ca²⁺) from the blood. The hydrogel tube is used to connect the ex vivo arteriovenous shunt circuit or implanted into the left carotid artery in the rabbit model, showing a better patency rate. All of these results suggest that this hydrogel tube may mitigate infection and thrombosis complications, thus holding potential as an artificial blood vessel for emergency vascular replacement.