… DNA methylation and HDAC activity can modulate … loss and HDAC inactivation can lead
to changes in chromatin accessibility and transcription factor occupancy, we next examined the …

… transcription factors on single DNA molecules at mouse CREs. Analysis of the binary
occupancy … or repress transcription by recruiting protein complexes that modulate the activity of …

… challenge: DNA methylation seldom evokes a severe response; rather it modulates binding
… when comparing differences in TF occupancy between methylated and unmethylated sites (i) …

… DNA methylation is an important epigenetic modification which has numerous roles in modulating
genome function. … gain upon evolutionary loss of TF occupancy, indicating coordinated …

… hypothesised that aberrant methylation patterns could be controlled by the binding of specific
transcription factors (TFs) across cancer types. By combining DNA methylation arrays and …

… Next, we asked whether CREB1 binds 5' LTR regions of IAPLTR1/1a elements in the
absence of DNA methylation. To benchmark our ability to measure occupancy at repetitive …

… of cell-type-specific enhancers where DNA methylation antagonizes the binding of transcription
… , DNA methylation directly controls transcription factor occupancy at active enhancers. …

… To confirm the key role of TFs in modulating local DNA methylation profiles, we compared
the effect on local DNA methylation between SNV-TFBSs and SNVs that lie adjacent to but …

… regulatory elements (CREs) that function as regulatory switches to modulate the expression
of genes. … Molecular co-occupancy identifies transcription factor binding cooperativity in vivo. …

… (R 2 = 0.43) outperformed all other marks, with marks of active chromatin such as RNA
polymerase II occupancy, H3K4me3, open chromatin, and H3K27ac showing poor correlations (R …