… ’s disease, and acute neuropathological conditions such as … of calcium-mediated toxicity,
highlighting its role from the … and extrasynaptic NMDA receptors mediating neuroprotection …

… Glutamate, the major excitatory neurotransmitter in the brain … glutamate receptors and
metabotropic glutamate receptors (… This glutamate-glutamine shuttle is the key for glutamatergic …

… Several presumptions have been put forward to explain the cause of AD neuropathology …
the complex role played by glutamate receptors in AD and PD. Glutamatergic signaling …

… might disturb NMDAR-dependent physiological function and non-neuronal NMDAR
related signaling. Previous studies have indicated that memantine could function on non-neuronal …

… The neuropathological hallmarks of AD are the presence of extracellular senile β-amyloid
(… CaMKII is activated by acute Aβ42 stimulation but becomes deactivated following prolonged …

… NMDA receptors and the regulatory role of the GluN3 subunit. Functional NMDA receptors
are transmembrane heterotetramers embedded in the phospholipid bilayer of glutamatergic …

… The role of NMDAR-mediated excitotoxicity, primarily via excessive Ca 2+ influx through
the extrasynaptic GluN2B-containing receptors, in the context of both acute and chronic …

… of glutamatergic dysfunction in depression and other disorders. Glutamatergic involvement
across diverse neuropathologies … Commonly resulting from acute or chronic liver disease or …

… postsynaptic site of glutamatergic synapses causes membrane … tangles comprise the major
neuropathological lesions in AD … Kainate receptors mediate a slow postsynaptic current in …

… pathogenesis of acute seizure and chronic epilepsy. Some … seizures and produce
neuropathological lesions similar to those … glutamate receptors modulate glutamatergic signaling …