… The biological function of VEGF-B has long been poorly understood. Despite its
sequence homology with VEGF-A 21 , its role in angiogenesis is limited to conditions of over-expression …

… of pancreatic cells, particularly β-cell and endothelial cells.… can cause a deleterious effect
on an islet cell function in… and PDGF play a major role in pancreatic β-cells regeneration, the …

… Since beta cells produce both VEGF-A and PlGF, we then examined expression of both VEGF-A
and PlGF in beta cells in … Interestingly, we found that VEGF-A levels in beta cells remain …

… the vascular cells and β-cells and its role in glucose homeostasis and diabetes. … cells and
neurons (1–4). This review focuses on the crosstalk of β-cells with vascular cells and their role …

… Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in
pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50:…

… The aim of the present study was to investigate the role of the PKCβII/HuR/VEGF-A pathway
in the development of DR using the Ins2 Akita mouse animal model, which is characterized …

… starting one day before VEGF-A induction and continuing for 1 week after VEGF-A normalization
(Fig. 2a). … , NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, PI3K …

… However, whether VEGF-B directly functions by binding VEGFR1 or competing with VEGF-A
to promote the binding of VEGF-A and VEGFR2 to activate downstream signaling pathways …

… of surface VEGFR2 and diminished VEGF-A–triggered signal … function assays, we provide
88 new evidence that pancreatic islet endothelial cells develop resistance against VEGF-A …

… to which it accumulates in the B cells of the pancreas and leads to their death with the
subsequent development of diabetes. Defeat of B-cells is accompanied by degenerative changes …