… Regardless of potent cathepsin B inhibition, no cell death … in IFN-γ induced cathepsin S
expression in infected cells. On … 10 induction to block cathepsin S dependent processing of Ii in …

… mucosal inflammation and tissue remodeling. Transcriptional … and epithelial cells and
examine functional significance in … These studies implicate IFN-γ-induced epithelial dysfunction …

… airway disease that presents with different types and degrees of inflammation often in
association with airway … and/or neutrophils and resident airway structural cells participate in the …

… Cathepsin S-dependent epithelial cell apoptosis is a crucial event in the pathogenesis of
IFN-γ-induced alveolar … The fate of lung alveolar cells in emphysema is shown in Fig. 38.3. …

… It is thought to play a role in the pathogenesis of COPD via expression from dysregulated
monocytes [27] and subsequent apoptosis of cells in the alveolar wall [28], leading to the loss …

… released from epithelial cells, alveolar type 2 epithelial cells, endothelial cells, mast cells, …
In addition, emphysema has been associated with apoptosis in the cells of the alveolar wall, …