… The role of connexin proteins in the control of homeostasis remains to be elucidated. It has
been suggested that specific parts of connexin proteins directly affect gene transcription. Thus…

… One way by which connexins regulate biological processes is by controlling the gap junction
mediated intercellular transfer of second messengers. Thus functional assays which can …

… -independent roles of connexins in blood vessel function … connexin functions constitute
an often underestimated basis for the enormous plasticity of vascular morphology and function …

… tumor growth [67]. The hypothesis of the main role of Gj in the control of tumor growth by …
cell proliferation and primary tumor growth [69,70]. One of the mechanisms that explains the …

… The specific permeability of various Cx plays a role in GJIC-mediated growth control mechanisms.
In … Cx can also control tumour growth through channel-independent mechanisms. The …

… genes; connexin genes took over the gap junction function for the first time in the deuterostomes
[3]. Innexin- and connexin-… This connexin–innexin dichotomy suggests a convergent …

… examination of the role of connexins in cardiac pathophysiology… , cardiac fibrosis, gene
transcription or signaling regulation. … exert a control over these functions thanks to the presence of …

… [1] described that connexins genes could exert a differential cell growth control effect,
depending on the cell type in which they are expressed. Further studies in corticotropinomas are …

… the Genetic Testing Registry or a PubMed search of disease-associated connexin gene
variants that require further patient studies to confirm linkage. Connexin gene polymorphisms …

… of GJIC; (4) Cx gene transfection inhibits the growth and decreases the tumorigenicity of
tumor cells [19, 20]; (5) Mice with connexin-32 knockout can develop spontaneous and …