Role of integrins in modulating smooth muscle cell plasticity and vascular remodeling: from expression to therapeutic implications

M Jain, AK Chauhan - Cells, 2022 - mdpi.com
… and αvβ3-specific antagonists, RGD peptide, or integrin blocking … Previous preclinical and
clinical studies emphasizing αvβ3 … the role of other integrins in SMC biology could lead to new …

The effects of αvβ3 integrin blockage in breast tumor and endothelial cells under hypoxia in vitro

BC Casali, LT Gozzer, MP Baptista, WF Altei… - International Journal of …, 2022 - mdpi.com
… of αvβ3 integrin blocking upon treatment with DisBa-01. Due to the essential role of the αvβ3
integrin … of the tumor and endothelial cells upon αvβ3 integrin blockade, depending on the …

Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3

L Zhong, L Tang, X He - Bioengineered, 2022 - Taylor & Francis
… Upregulated expression of αvβ3 promoted blood vessel formation … suppressor in CC through
integrin αvβ3, which provides a … provide evidence supporting the role of integrin αvβ3 in the …

Integrin-αvβ3 as a therapeutic target in glioblastoma: back to the future?

W Echavidre, V Picco, M Faraggi, C Montemagno - Pharmaceutics, 2022 - mdpi.com
… of the different roles fulfilled by integrin-αvβ3 in GBM, as well as different therapeutic strategies
developed to target integrin-αvβ3. We finally emphasized the theranostic-dedicated αvβ3-…

The role of integrins in inflammation and angiogenesis

OJ Mezu-Ndubuisi, A Maheshwari - Pediatric research, 2021 - nature.com
… and function of integrins; the mechanisms involved in integrin activation and signaling; their
role in inflammation, infection, and angiogenesis; and discuss current advances in integrin-…

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications

S Zhang, Q Zhang, Y Lu, J Chen, J Liu, Z Li… - International Journal of …, 2024 - mdpi.com
… , vascular smooth muscle cells, platelets, fibroblasts, cardiomyocytes, and various immune
cells. The crucial role of integrins in the … Conversely, αVβ3 integrins and β1 integrins with talin-…

There is a world beyond αvβ3-integrin: multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

K Steiger, NG Quigley, T Groll, F Richter, MA Zierke… - EJNMMI research, 2021 - Springer
… to αvβ3-integrin with high … αvβ3-integrin plays a major role in angiogenesis, ie, the sprouting
of new vessels from existing ones (to be distinguished from de-novo formation of vasculature

OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature

TT Wing, DW Erikson, RC Burghardt, FW Bazer… - …, 2020 - rep.bioscientifica.com
… osteopontin near placental blood vessels. In summary, OPN binds the αv integrin subunit
on … Although the αvβ3 integrin is accepted as the primary OPN receptor, OPN binds multiple …

Nano-strategies targeting the integrin αvβ3 network for cancer therapy

TM Cheng, WJ Chang, HY Chu, R De Luca… - Cells, 2021 - mdpi.com
… However, our study suggested that the integrin αvβ3-targeted function of NDAT increased
the efficacy of chemotherapy of first-line anticancer drugs. Although studies may not show …

Role of αVβ3 in prostate cancer: Metastasis initiator and important therapeutic target

L Tang, M Xu, L Zhang, L Qu, X Liu - OncoTargets and therapy, 2020 - Taylor & Francis
… Although the mechanism of malignant tumor metastasis is unclear, studies have
confirmed that integrin αVβ3 plays an important role in this process. In prostate cancer, …