… Inhibition of putrescine formation by DFMO led to the up-regulated the hydrogen peroxide
… with angiogenesis and polyamine metabolic processes. Further investigation revealed that …

… for this interconversion process, arerather low in rat heart;41 •… into putrescine; however, the
formation of putrescine via this … the metabolic and contractile activity of the heart cell closely …

… This process can be enhanced by histamine and blocked by … in supernatants with 14 C-putrescine
(300 μM) as substrate. … : 10 mM histidine increased force of contraction by 27% from …

… and increase susceptibility to Ang II-induced AAA formation in … , putrescine affected the
switch of VSMCs from contractile to … microscopy or other methods. Transmission electron …

… Methods: In the current study, we aimed to characterize the … that putrescine and acetyl-spermidine
were increased in … ) improves contractile function in rats with hypertrophying hearts [64]…

… by the increased GABA abundance and its precursors’ putrescine, … or a lower rate of formation
in MS, necessitating additional … of IDH2 induces contractile dysfunction in the heart, and it …

… to protect the aging heart from contractile dysfunction through inhibition … and necrotic core
formation by inducing autophagy in an … methods [37]. Polyamine content was measured using …

… our understanding of these processes remains 31 incomplete … pathway that leads to putrescine
formation that 206 does not … for the heart 431 rhythm and cardiac muscle contraction, is a …

… , and the coupling of receptors to messenger formation. … the Stimulation of contractility and
rate, whereas putrescine (0.5 … on cardiac contractility via a polyamine-dependent process. This …

… AGAT also catalyzes the formation of guanidinoacetate (GAA) … as the polyamines putrescine
and spermidine in the heart, lung, … The catalytic process includes a nucleophilic attack of the …