Regulation of HTLV-1 transformation

KJ Ernzen, AR Panfil - Bioscience reports, 2022 - portlandpress.com
… the important viral and cellular factors involved in HTLV-1 … Tax can also protect HTLV-1-infected
cells from apoptosis … remaining viral accessory proteins of HTLV-1 also play a key role in …

HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
… HBZ and discuss its significance in pathogenesis by HTLV-1. … proliferation and inhibits the
apoptosis of expressing T cells, … This function of HBZ RNA is particularly beneficial for HTLV-1

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
… oncogenic viruses, HTLV-1 specifically targets apoptosis … ; re-expression of BIM induced
apoptosis in ATLL cell lines [160… by inhibiting the function of the FoxO3a transcription factor [161]…

HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
role in the outcome of HTLV-1-induced … using HTLV-1 virus isolated from MT-2 supernatants,
SAMHD1 has been described to exert its antiviral activity by inducing apoptosis of HTLV-1-…

HTLV1 oncovirus‐host interactions: From entry to the manifestation of associated diseases

S Ahmadi Ghezeldasht, SAA Shamsian… - Reviews in medical …, 2021 - Wiley Online Library
HTLV-1 Tax also reduces the expression of the apoptosis … Tax play an essential role in
the HTLV-1 transmission. The … of viral infection, particularly HTLV-1, why are HTLV-1 specific …

Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system …

K Ghazvini, M Youssefi, M Keikha - Access Microbiology, 2020 - microbiologyresearch.org
… of HTLV-1 virulence factors and the resistance of HTLV-1-… The purpose of this study
was to investigate the expression … and NSC 617145 induce apoptosis in HTLV-1-transformed …

The Role of Chemokines in the Pathogenesis of HTLV-1

R Zargari, M Mahdifar, A Mohammadi… - Frontiers in …, 2020 - frontiersin.org
… Human T cell leukemia virus type 1 (HTLV-1) is a human … Evidence also suggests viral
and environmental factors, the … cell with induction of NF-kB, and resistance to apoptosis, by …

HTLV-1 replication and adult T cell leukemia development

CZ Giam - Viruses and Human Cancer: From Basic Science to …, 2021 - Springer
… Its role in HTLV-1 infection and replication cycle is not fully … cellular senescence or apoptosis.
In a small fraction of … needed or alternative viral factor(s) (such as HBZ) is (are) involved. …

Autophagy in human T-cell leukemia virus type 1 (HTLV-1) induced leukemia

N Ducasa, D Grasso, P Benencio… - Frontiers in …, 2021 - frontiersin.org
… with unfavorable prognostic factors are aggressive forms and … proteins play a critical role in
HTLV-1 infection as well as in … processes such as senescence and apoptosis has been vastly …

HIV-1 and HTLV-1 transmission modes: Mechanisms and importance for virus spread

S Kalinichenko, D Komkov, D Mazurov - Viruses, 2022 - mdpi.com
… HIV replication induces the apoptosis of CD4 lymphocytes, leading to the development of …
RNA, which encodes the HTLV-1 basic leucine zipper factor protein Hbz and its splicing …