… plasminogen activators (uPA/tPA) convert plasminogen into the active enzyme plasmin, which
in turn activates matrix metalloproteinases and degrades the extracellular matrix releasing …

… , invasion, angiogenesis, and inflammation. … Plasmin is also able to activate matrix
metalloprotease (MMP) zymogens, which play a key role in the degradation of the extracellular …

… discussion of the roles of plasminogen activation system in tumor growth, … by proteases, such
as matrix metalloproteases (MMPs) (… For instance, the pro-angiogenic function is due to the …

… plasminogen into plasmin, which consequently leads to disruption of the extracellular matrix
… mediating cancer progression, by enhancing angiogenesis, promoting tumor cell migration …

… of fellow proteases, such as matrix metalloproteinases (MMPs), … protease plasmin by tissue-type
plasminogen activator (tPA) … growth factor and thus suppression of tumor angiogenesis. …

… of the plasminogen system, plasminogen activator inhibitor-1 (… through the modulation
of matrix metalloproteinase (MMP) … role on plasmin activation diminishes the cleavage-mediated …

… plasmin to the multifaceted role of this system. In addition to fibrinolysis, PAS plays a central
… platelet functions and plasminogen activator uPA has also been found in angiogenesis. It is …

… Tissue-type (tPA) and urokinase-type (uPA) plasminogen activators … Conversely, both matrix
metalloproteinases and plasmin … Angiogenesis is the complex process of new blood vessel …

… plasminogen activators including tissue-type plasminogen … convert the proenzymes of matrix
metalloproteinases (MMPs) to … to as angiostatin, an endogenous angiogenesis inhibitor [22]. …

… MMP-9 pro-angiogenic function is protected by NGAL … a role in the activation of MMPs
and plasminogen activator (PA… uPAR involved in the activation of plasminogen to plasmin. …