Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs

YC Boo - Antioxidants, 2024 - mdpi.com
… to discuss the antifibrotic effects of rosmarinic acid (RA) and … , have been shown to
attenuate fibrosis of the liver, kidneys, … apoptosis in the activated hepatic stellate cell line (HSC-T6), …

Lemon balm and its constituent, rosmarinic acid, alleviate liver damage in an animal model of nonalcoholic steatohepatitis

M Kim, GH Yoo, A Randy, YJ Son, CR Hong, SM Kim… - Nutrients, 2020 - mdpi.com
… , rosmarinic acid (RA), effectively improve the liverhepatic stellate cells recruit circulating
immune cells and are differentiated to myofibroblasts, which ultimately results in liver fibrosis

SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH)

T Komeili-Movahhed, M Bassirian… - Journal of Receptors …, 2022 - Taylor & Francis
… 19–21] and attenuates apoptosis and fibrosis in the renal cells, … Rosmarinic acid attenuated
apoptosis pathway related … fact, hepatic lipid accumulation triggers hepatic stellate cells, …

[PDF][PDF] The Effects of Rosmarinic Acid on the Liver Fibrosis Induced by Non-alcoholic Steatohepatitis in Male Mice

A Moslehi, T Komeili-Movahed - Qom University of Medical …, 2021 - scholar.archive.org
… , and hepatocellular carcinoma. Rosmarinic Acid (RA) is a powerful antioxidant and anti-…
role of RA on a mouse model of NASH-induced liver fibrosis. Methods In this research, C57/BL6 …

Inhibition of p66Shc oxidative signaling via CA-induced upregulation of miR-203a-3p alleviates liver fibrosis progression

Z Wang, Y Zhao, H Zhao, J Zhou, D Feng… - … Therapy-Nucleic Acids, 2020 - cell.com
… against hepatic stellate cell (HSC) activation during liver fibrosis… means to attenuate the
progression of liver fibrosis. However, … Relevance of carnosic acid, carnosol, and rosmarinic acid

Rosmarinic acid alleviates toosendanin-induced liver injury through restoration of autophagic flux and lysosomal function by activating JAK2/STAT3/CTSC pathway

L Luo, J Lin, S Chen, J Ni, H Peng, F Shen… - Journal of …, 2024 - Elsevier
… This study demonstrated that RA attenuated TSN-caused … Rosmarinic acid attenuates
hepatic steatosis by modulating ER stress and autophagy in oleic acid-induced HepG2 cells

A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids

X Pan, X Ma, Y Jiang, J Wen, L Yang… - Evidence‐based …, 2020 - Wiley Online Library
… (ECM) accumulation and hepatic stellate cell (HSC) activation. A … mg/kg significantly attenuated
liver damage and liver fibrosis … that rosmarinic acid inhibited liver fibrosis progression by …

Rosmarinic acid prevents radiation-induced pulmonary fibrosis through attenuation of ROS/MYPT1/TGFβ1 signaling via miR-19b-3p

T Zhang, S Ma, C Liu, K Hu, M Xu… - Dose-Response, 2020 - journals.sagepub.com
… It has been reported that RA attenuates airway inflammation by mediating the … suppresses
ROS production and lipid peroxidation whereas increases cellular GSH in hepatic stellate cells

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells

Z Li, L Jiang, J Ni, Y Xu, F Liu, W Liu, S Wang… - Acta Pharmacologica …, 2023 - nature.com
… in the pathogenesis of hepatic fibrosis. We first found that UGCG was over-expressed in
fibrotic livers and activated hepatic stellate cells (HSCs). In human HSC-LX2 cells, inhibition of …

[PDF][PDF] Protective Effect of Rosmarinic Acid on Inflammatory Changes of Hepatic Cells in Non-alcoholic Steatohepatitis in Mice: Cyclooxygenase 2/Prostaglandin E2 …

T Komeili-Movahhed, A Moslehi - Qom Univ Med Sci J, 2023 - sid.ir
Methods In this study, 24 C57/BL6 male mice were used. They were divided into four groups
of 6 including; Control, RA, NASH, and NASH+ RA. The NASH was induced by a methionine…