HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
… by studies based on cellular models on HTLV-1 infection and … to HTLV-1 infection, Japanese
monkeys infected by STLV-1 … virus-infected T cells, representing a valid model for studying

Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model …

Y Seki, T Kitamura, K Tezuka, M Murata, H Akari… - Viruses, 2022 - mdpi.com
… of rVSV in an STLV-1-infected NHP model is suitable as a preclinical study. In this study, we
… a neutralizing antibody against STLV-1 Env in this study because STLV-1 Env has the same …

In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions

M Izaki, J Yasunaga, K Nosaka, K Sugata… - PLoS …, 2021 - journals.plos.org
… In this study, we analyzed dynamics of infected cells in various clinical … model for HTLV-1
infection. We have previously reported that STLV-1-infected JMs are similar to HTLV-1-infected

STLV-1 Commonly targets neurons in the brain of asymptomatic non-human primates

B Rocamonde, S Alais, R Pelissier, V Moulin… - Mbio, 2023 - Am Soc Microbiol
infected by STLV-1 to investigate HTLV-1 neural infection in vivo. This unique model allowed
us to investigate HTLV-1 … , our study emphasizes the use of naturally STLV-1-infected NHP …

Antiretroviral therapy in HTLV-1 infection: an updated overview

F Marino-Merlo, E Balestrieri, C Matteucci, A Mastino… - Pathogens, 2020 - mdpi.com
… acid in STLV-1 naturally infected primates, as preclinical models of asymptomatic carriers
of … Results of this study, performed using HTLV-1 chronically infected cell lines as well as …

Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL …

A Hasegawa, M Murata, T Fujikawa, K Katagiri… - PLoS …, 2023 - journals.plos.org
study, using Japanese monkeys that were naturally infected with simian T-cell leukemia/T-lymphotropic
virus type-1 (STLV-1) closely related to HTLV-1… rat model of oral HTLV-1 infection

… macaque model of human T-cell leukemia virus type 1 (HTLV-1) infection by direct inoculation of adult T-cell leukemia patient-derived cell lines for HTLV-1 infection

E Urano, K Ueda, M Higuchi, M Furukawa… - Journal of …, 2022 - Am Soc Microbiol
… In the present study, we established an NHP model of HTLV-1 infection using CMs as the …
those in Japanese macaques naturally infected with STLV-1 and some asymptomatic carriers (…

Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques

M Murata, J Yasunaga, A Washizaki, Y Seki… - Retrovirology, 2020 - Springer
… 9 years old were infected with STLV-1, our results of this study … the STLV-1 was phylogenetically
distinct from the HTLV-1 [39]… terms of the distribution of STLV-1-infected JMs is observed, …

Mouse Models for HTLV-1 Infection and Adult T Cell Leukemia

S Nakajima, K Okuma - International Journal of Molecular Sciences, 2023 - mdpi.com
infection. This review outlines the characteristics of mouse models of HTLV-1 infection/ATL
and … STLV-1-infected monkey models have been used to study vaccines and therapeutics for …

Work-related human T-lymphotropic virus 1 and 2 (HTLV-1/2) infection: a systematic review

A Stufano, HR Jahantigh, F Cagnazzo, F Centrone… - Viruses, 2021 - mdpi.com
… The study aim was to investigate the possible interspecies transmission from NHPs to humans
of STLV-1, the virus from which HTLV-1 … these transmission models, no cases of HTLV-1/2 …