Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism: Association with Risk and Severity of Premature Coronary Artery Disease
WES Saad, MM Abd Al Aziz, MESA Fathi… - The Egyptian Journal …, 2020 - journals.ekb.eg
WES Saad, MM Abd Al Aziz, MESA Fathi, AA Abdeltawab, HA Abdel Sattar
The Egyptian Journal of Hospital Medicine, 2020•journals.ekb.egBackground: Many different genetic associations with premature coronary artery disease
(PCAD) have been identified. One exonic single nucleotide polymorphism (SNP) rs5888 of
Scavenger receptor class B type1 (SCARB 1) gene has been linked to lipid traits as well as
subclinical atherosclerosis. Objective: To investigate the association between SNP rs5888 of
SCARB 1 gene and PCAD risk and severity. Patients and Methods: This study was
conducted on 50 Egyptian patients diagnosed as PCAD by coronary angiograph (PCAD …
(PCAD) have been identified. One exonic single nucleotide polymorphism (SNP) rs5888 of
Scavenger receptor class B type1 (SCARB 1) gene has been linked to lipid traits as well as
subclinical atherosclerosis. Objective: To investigate the association between SNP rs5888 of
SCARB 1 gene and PCAD risk and severity. Patients and Methods: This study was
conducted on 50 Egyptian patients diagnosed as PCAD by coronary angiograph (PCAD …
Background
Many different genetic associations with premature coronary artery disease (PCAD) have been identified. One exonic single nucleotide polymorphism (SNP) rs5888 of Scavenger receptor class B type1 (SCARB 1) gene has been linked to lipid traits as well as subclinical atherosclerosis.
Objective
To investigate the association between SNP rs5888 of SCARB 1 gene and PCAD risk and severity.
Patients and Methods
This study was conducted on 50 Egyptian patients diagnosed as PCAD by coronary angiograph (PCAD group) and (50) age- and sex-matched non-CAD subjects who showed no luminal stenosis in coronary angiographic served as a control group (non-CAD group). Gensini score was calculated as an indication for atherosclerosis severity for patients only. Detection of rs5888 polymorphism of SCARB 1 gene was done by realtime polymerase chain reaction (PCR) and high resolution melting analysis (HRM).
Results
The mutant TT and CT genotypes were more frequently distributed in PCAD group compared to nonPCAD group (34 % and 48 % vs. 26 % and 18 %, respectively). The (CT) genotype conferred a positive risk for PCAD in males (OR: 6.117, 95% CI (1.744-21.452); p < 0.01). T allele conferred a positive risk for PCAD (OR: 2.564, 95% CI (1.440-4.543); p < 0.05). Highest Gensini score was found in PCAD patients with (TT) genotype (p < 0.01).
Conclusion
The mutant (CT) genotype and the T allele of SCARB 1 SNP rs5888 were associated with increased risk of PCAD and the mutant (TT) genotype was associated with disease severity calculated by Gensini score.
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