Beta-KTx14. 3, a scorpion toxin, blocks the human potassium channel KCNQ1

G Titaux-Delgado, AE Lopez-Giraldo, E Carrillo… - … et Biophysica Acta (BBA …, 2023 - Elsevier
… Our findings provide insights for the development of novel toxin-based drugs for … peptides,
a group of antimicrobial defensins [7]. Pro-peptides, potassium channel toxins, and peptides

Artificial Peptide Ligand of Potassium Channel KV1.1 with High Selectivity

VM Tabakmakher, AI Kuzmenkov, AM Gigolaev… - Journal of Evolutionary …, 2021 - Springer
… of MeKTx13-3, a peptide toxin from the venom of the scorpion Mesobuthus eupeus. The …
rare feature of polypeptide ligands of K V s [23]. Now we report that the introduction of a number …

[HTML][HTML] Peptide inhibitors of Kv1. 5: an option for the treatment of atrial fibrillation

J Borrego, A Feher, N Jost, G Panyi, Z Varga, F Papp - Pharmaceuticals, 2021 - mdpi.com
… All known scorpion toxins affecting potassium channels (KTx) … to scorpion venom peptides,
spider venom peptides are … The overall methodological background and information on …

Pharmacology of Potassium Channels

S Deka, P Borah, R Bania, S Das, PK Deb - Frontiers in Pharmacology of …, 2020 - Springer
… of K + channels and offers an updated overview on the progress … two types: peptide venom
toxins and small molecules. The … (eg toxins from snakes, sea anemones, scorpions and cone …

… of Two Kv1.3 Channel Blockers from Scorpion Mesobuthus eupeus and Sea Anemone Stichodactyla haddoni and Construction of their Chimeric Peptide as a Novel …

M Asadi, H Ayat, AM Ahadi, MS Ranjbar - Biochemical Genetics, 2022 - Springer
… The size of the signal peptide is in the range of the potassium channel toxins, between
21 and 25 … The schematic view of the interaction of the shtx-k, MeuKTX, and their chimeric …

[HTML][HTML] BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway

F Zhao, X Zou, S Li, J He, C Xi, Q Tang, Y Wang, Z Cao - Toxins, 2021 - mdpi.com
… a new scorpion peptide designated to be BmK neurite-stimulating peptide targeting K v channels
(NSPK) from BmK venom. … In summary, we purified a potent potassium channel blocker, …

Chemical Approaches to Improve the Manufacturability of Disulfide-Rich Peptide Toxins: Engineering a Stable and Selective Peptide Blocker of the KCa1. 1 Channel

EM Delgado - 2022 - search.proquest.com
… Unfortunately, many scorpion venom 203 peptides feature … In the past, venom peptides
have been invaluable in probing … The bioengineering of scorpion toxins to enhance their 860 …

[PDF][PDF] Current Status of Peptide Medications and the Position of Active Therapeutic Peptides with Scorpion Venom Origin

M Baradaran - Jundishapur Journal of Natural Pharmaceutical …, 2023 - brieflands.com
… In this review, we tried to represent the current status of peptide medicines and … Scorpion
toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. …

Neurotoxicity induced by scorpion venom

LL Valdez-Velazquez, JM Jiménez-Vargas… - Natural Molecules in …, 2024 - Elsevier
Scorpion venom toxins with affinity to the potassium … The neurotoxic peptides of scorpion
venom act on the function of … This review showed a broad overview of the signs and symptoms …

Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico

LL Valdez-Velázquez, J Cid-Uribe… - Toxicon, 2020 - Elsevier
Scorpion venom components include proteins, peptides, and … of Kv1 family and BK K +
channels (reviewed in Jimenez-… showing identity with different potassium channel toxins (10 α…