[HTML][HTML] Androgen receptor and cardiovascular disease: a potential risk for the abuse of supplements containing selective androgen receptor modulators

E Hall, MF Vrolijk - Nutrients, 2023 - mdpi.com
androgen receptor (AR) is a member of the family of ligand-activated transcription factors.
Selective androgen receptor modulators (… significantly increase their clinical application in the …

Adverse effects and potential benefits among selective androgen receptor modulators users: a cross-sectional survey

IV Efimenko, D Valancy, JM Dubin… - International journal of …, 2022 - nature.com
Selective androgen receptor modulators (SARMs) are a class of androgen receptor ligands
that bind androgen receptors and display tissue selective activation of androgenic signaling. …

Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications

C Pisano, M Tucci, RF Di Stefano, F Turco… - Critical reviews in …, 2021 - Elsevier
Understanding the interplay between androgen receptor signaling and these molecular …
To the best of our knowledge, there are currently no drugs in development that target TP53 …

[HTML][HTML] Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: analysis of suspected cases

N Leciejewska, K Jędrejko, VM Gómez-Renaud… - … Journal of Clinical …, 2024 - Springer
Selective androgen receptor modulators (SARMs) have demonstrated agonist activity on the
androgen receptor … injury cases associated with the use of SARM agonists by humans and …

[HTML][HTML] Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth

MD Nyquist, LS Ang, A Corella… - … Journal of clinical …, 2021 - Am Soc Clin Investig
Recent clinical studies have exploited this effect by administration of supraphysiological …
T, resulting in clinical responses and improvements in quality of life. However, the use of T as a …

[HTML][HTML] An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer

ML Mohler, A Sikdar, S Ponnusamy, DJ Hwang… - International journal of …, 2021 - mdpi.com
use of current and next-generation AR-targeted therapy [9]. … structure of a selective androgen
receptor modulator (SARM) … structure of a selective androgen receptor modulator (SARM) …

Androgen receptor expression in breast cancer: Implications on prognosis and treatment, a brief review

N Jahan, C Jones, RL Rahman - Molecular and Cellular Endocrinology, 2021 - Elsevier
Selective androgen receptor modulators Selective androgen receptor modulators (SARMs)
are chemically engineered small molecules that can selectively exert varying agonist and …

Is it time to consider the Androgen receptor as a therapeutic target in breast cancer?

MK Forooshani, R Scarpitta, GN Fanelli… - … (Formerly Current …, 2022 - ingentaconnect.com
… and its clinical implication in different subtypes of breast cancer, as well as discuss clinical
trials targeting AR for the more effective treatment of breast cancer. We also present our view …

[HTML][HTML] Androgen receptor signaling pathway in prostate cancer: from genetics to clinical applications

G Aurilio, A Cimadamore, R Mazzucchelli… - Cells, 2020 - mdpi.com
androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction
in serum androgens and the inhibition of androgen receptor … response to androgen ablation …

Newly developed targeted therapies against the androgen receptor in triple-negative breast cancer: A review

E Choupani, MM Gomari, S Zanganeh, S Nasseri… - Pharmacological …, 2023 - ASPET
… is currently used as the primary approach against TNBC. Expression of androgen receptor
(… with TNBC; therefore, inhibiting androgen signaling pathways holds promise for TNBC …