[HTML][HTML] Temporal Characterization of Behavioral and Hippocampal Dysfunction in the YAC128 Mouse Model of Huntington's Disease
C de Paula Nascimento-Castro… - Biomedicines, 2022 - mdpi.com
… N-terminal region of huntingtin (htt). Even though mutant huntingtin (mHTT) is ubiquitously
expressed throughout the body, it causes selective neuronal degeneration, particularly in the …
expressed throughout the body, it causes selective neuronal degeneration, particularly in the …
[HTML][HTML] A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
A Kotowska-Zimmer, L Przybyl, M Pewinska… - … Therapy-Nucleic Acids, 2022 - cell.com
… selectively reduce the mutant huntingtin level in cellular models of HD. The purpose of this
study was to test the efficacy, selectivity, … to the brains of YAC128 mice via intrastriatal injection …
study was to test the efficacy, selectivity, … to the brains of YAC128 mice via intrastriatal injection …
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains
… (≥60%) nuclear localization. A deeper investigation into the … This change might be due to
selective degeneration of … we used the B97-ΔN17 and YAC128 mouse models due to their …
selective degeneration of … we used the B97-ΔN17 and YAC128 mouse models due to their …
[HTML][HTML] Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
K Bečanović, M Asghar, I Gadawska… - npj Aging and …, 2021 - nature.com
… the effects of mutant huntingtin on mitochondrial parameters … of HD is the selective
degeneration of the basal ganglia, with … increased in old YAC128 compared to young YAC128 …
degeneration of the basal ganglia, with … increased in old YAC128 compared to young YAC128 …
[HTML][HTML] Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
… Lowering mHTT in the brain of YAC128 mice is not sufficient to rescue aberrant palmitoylation.
However, we demonstrate that mHTT palmitoylation can be normalized in COS-7 cells, in …
However, we demonstrate that mHTT palmitoylation can be normalized in COS-7 cells, in …
Altered cortico-striatal signaling and motor behaviour in the YAC128 mouse model of Huntington disease
ET Koch - 2022 - open.library.ubc.ca
… Mice showed increased neuronal activity on the rotarod, which diminished by late stages of
learning. 2–3-month-old YAC128 mice … Striatal degeneration has been shown in R6/2 mice …
learning. 2–3-month-old YAC128 mice … Striatal degeneration has been shown in R6/2 mice …
[HTML][HTML] DAPK1 promotes extrasynaptic GluN2B phosphorylation and striatal spine instability in the YAC128 mouse model of Huntington disease
… Although striatal and cortical neurons eventually degenerate… selective DAPK1 inhibitor
(TC-DAPK6) decreased exGluN2B pS1303 levels in cortical tissue from 4-week-old YAC128 mice…
(TC-DAPK6) decreased exGluN2B pS1303 levels in cortical tissue from 4-week-old YAC128 mice…
Investigating the Role of Mutant Huntingtin mRNA in Huntington's Disease
S Ly - 2020 - repository.escholarship.umassmed …
… mutant HTT mRNA in pathology or pathogenesis. Here we report that in two HD mouse models,
YAC128 and BACHD-97QΔN17, mutant … mechanism of selective striatal degeneration in …
YAC128 and BACHD-97QΔN17, mutant … mechanism of selective striatal degeneration in …
Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model
M Laroche, M Lessard-Beaudoin… - Human Molecular …, 2020 - academic.oup.com
… is an early phenotype in the YAC128 mice and concurrent with … receptor neurons and their
selectivity may contribute to olfactory … dysfunction and degeneration due to mutant huntingtin …
selectivity may contribute to olfactory … dysfunction and degeneration due to mutant huntingtin …
[HTML][HTML] Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
EC Kuijper, M Overzier, E Suidgeest… - Neurobiology of …, 2024 - Elsevier
… Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated
from the mutant huntingtin … ameliorate the consequences of mutant HTT without lowering …
from the mutant huntingtin … ameliorate the consequences of mutant HTT without lowering …