As butyrylcholinesterase (BChE) plays a role in the progression of symptoms and pathophysiology
of Alzheimer’s disease (AD), selective inhibition of BChE over acetylcholinesterase (…

… Selective BChE inhibition has been regarded as a viable therapeutic approach in Alzheimer’s
disease… As of now, a limited number of selective BChE inhibitors are available. To identify …

… is the replacement of aromatic residues in the active site of AChE with aliphatic ones in BuChE,
which in turn leads to enzyme selectivity [… involved during Alzheimer disease progression …

… In addition, Butyrylcholinesterase (BuChE) has also been … A similar but much smaller
difference in selectivity was … with cholinesterase inhibition, they may be an attractive alternative to …

… butyrylcholinesterase (BChE) play important roles in human neurodegenerative disorders
such as Alzheimer’s disease… ) models, a practical and effective alternative to traditional wet lab …

… nomenclature, they can also be known by alternative names. AChE … Currently, extensive
research on Alzheimers disease is also … is an example of a selective inhibitor; in this case, it is a …

… biological activity for validation of our triple inhibitor model. Finally, our findings suggest a
multi-target molecule for the treatment for Alzheimer’s disease, which can ultimately lead to an …

… candidate for the treatment of Alzheimer's disease in humans… of selective nanomolar
butyrylcholinesterase inhibitors (… study could represent a viable alternative to the currently …

… The recent development of highly selective BuChE inhibitors (2… Interaction section using
the option “define site from receptor … analogs as new inhibitors for Alzheimer disease. Bioorg. …

… ) and butyrylcholinesterase (BChE) inhibitors that can be utilized, eg, to treat Alzheimer's
disease. … Generally, the development of new selective AChE and BChE or dual inhibitors is still …