Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines

J Yang, K Li, D He, J Gu, J Xu, J Xie… - Drug Metabolism …, 2020 - Taylor & Francis
… pharmacokinetic models are comprehensively evaluated. This … For example, a self-microemulsifying
delivery system of … liposomal formulation enhanced the C max of oleanolic acid by …

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and …

JL Serrano, J Figueiredo, P Almeida… - … Alternative Medicine, 2020 - Wiley Online Library
… –loaded self-microemulsifying drug delivery system led to an … Given its potential as a
hypouricemic agent, ursolic acid is … further pharmacological evaluation, it is clear in this review that …

Unification of medicines and excipients: The roles of natural excipients for promoting drug delivery

M Feng, X Dai, C Yang, Y Zhang, Y Tian… - … on Drug Delivery, 2023 - Taylor & Francis
… The comparison of the drug delivery systems formed by NACs … oral administration can often
significantly improve the gastrointestinal absorption of drugs to obtain high oral bioavailability

Transdermal delivery of indirubin-loaded microemulsion gel: preparation, characterization and anti-psoriatic activity

E He, H Li, X Li, X Wu, K Lei, Y Diao - International journal of molecular …, 2022 - mdpi.com
… The present study intended to prepare and evaluate a … concentration, the self-microemulsifying
region was increased, and … drug delivery carrier to increase the transdermal flow of drugs, …

Development of phytochemical delivery systems by nano-suspension and nano-emulsion techniques

G Zuccari, S Alfei - International Journal of Molecular Sciences, 2023 - mdpi.com
oleanolic acid (OA) NSs (SEOA NSs) for enhanced deliverydrug delivery systems (SNEDDSs)
and self-microemulsifying … al. to improve RES bioavailability and was evaluated for its anti-…

[HTML][HTML] Lomustine's nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment

MH Alaayedi, NK Maraie - Saudi Pharmaceutical Journal, 2023 - Elsevier
drug lomustine had poor oral bioavailability in … improve solubility, avoiding first pass drug
metabolism and reduce systemic side effect of this chemotherapeutic agent as well as evaluate

[HTML][HTML] Physical characterization of clove oil based self Nano-emulsifying formulations of cefpodoxime proxetil: Assessment of dissolution rate, antioxidant & …

A Jindal, A Kumar - OpenNano, 2022 - Elsevier
… The present work aims to improve CPD solubilization by … , still it has low bioavailability. Since
CPD has aqueous … been utilized in the designing of lipid-based drug delivery systems as a …

Development and optimization of nanoemulsion containing exemestane using box-behnken design

S Chaturvedi, A Garg - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
… [9], self-microemulsifying drug delivery systems [10], … been investigated for improving the
oral bioavailability of EXE and … every individual run was statistically evaluated using Analysis of …

Nanotechnology in Nutraceuticals Delivery for the Prevention and Treatment of Cancer

OE Eyupoglu, K Saleem - Nutraceuticals in Cancer Prevention …, 2024 - taylorfrancis.com
… Similarly, nanoemulsions of ursolic and oleanic acid improvedEnhanced oral bioavailability
and improved biological … using a liquid self-microemulsifying drug delivery system. Planta …

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

K Mahmoud, S Swidan, M El-Nabarawi… - Journal of …, 2022 - Springer
… low drug bioavailability, and nonspecific drug delivery which … was entrapped with oleanolic
acid in liposomal formulation … model was used for the in vivo evaluation. The presence of …