[HTML][HTML] Hindsight: review of preclinical disease models for the development of new treatments for uveal melanoma
C Goldrick, L Palanga, B Tang, G Mealy… - Journal of …, 2021 - ncbi.nlm.nih.gov
… In recent years, there has been a growing repertoire of established UM cell lines derived
from primary and secondary patient tumours, or patient-derived xenografts (Table 1). Most of …
from primary and secondary patient tumours, or patient-derived xenografts (Table 1). Most of …
[HTML][HTML] Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study
S Leyvraz, F Konietschke, C Peuker, M Schütte… - European Journal of …, 2022 - Elsevier
… A precision oncology approach was feasible for patients with metastatic uveal melanoma,
with 60% receiving a therapy matched to identify molecular aberrations. The clinical benefit …
with 60% receiving a therapy matched to identify molecular aberrations. The clinical benefit …
Uveal melanoma: Progress in molecular biology and therapeutics
Uveal melanoma (UM) is the most common intraocular malignancy in adults. So far, no systemic
therapy or standard treatment exists to reduce the risk of metastasis and improve overall …
therapy or standard treatment exists to reduce the risk of metastasis and improve overall …
[HTML][HTML] FAK inhibitor-based combinations with MEK or PKC inhibitors trigger synergistic antitumor effects in uveal melanoma
M Tarin, F Némati, D Decaudin, C Canbezdi… - Cancers, 2023 - mdpi.com
… ORR of both monotherapies and combinations (E–H): In vivo efficacy of VS4718 with Trametinib
or LXS196 in 3 uveal melanoma patient-derived xenografts. Overall response rate (ORR…
or LXS196 in 3 uveal melanoma patient-derived xenografts. Overall response rate (ORR…
[HTML][HTML] Genetic landscape and emerging therapies in uveal melanoma
RS Seedor, M Orloff, T Sato - Cancers, 2021 - mdpi.com
… of the mutational landscape in metastatic uveal melanoma is needed. … the role of liquid
biopsies in uveal melanoma in this review. … Finally, UM patient-derived xenograft models suggest …
biopsies in uveal melanoma in this review. … Finally, UM patient-derived xenograft models suggest …
[HTML][HTML] Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma
D Decaudin, EFD Leitz, F Nemati, M Tarin… - European Journal of …, 2020 - Elsevier
… In vivo efficacy of ABT263 ± HDM201 in six uveal melanoma patient-derived xenografts. (A)
Overall response rate (ORR); the percentage in brackets correspond to an ORR lower than −…
Overall response rate (ORR); the percentage in brackets correspond to an ORR lower than −…
[HTML][HTML] Targeting Oncogenic Gαq/11 in Uveal Melanoma
D Lapadula, JL Benovic - Cancers, 2021 - mdpi.com
… whereas the growth of xenografts established from B-Raf mutant melanoma cells was
unaffected [120]. A second recent study using subcutaneous UM tumor xenografts of Gα 11 Q209L …
unaffected [120]. A second recent study using subcutaneous UM tumor xenografts of Gα 11 Q209L …
[HTML][HTML] Investigating the Role of DUSP4 in Uveal Melanoma
K Aughton, D Sabat-Pośpiech, S Barlow… - … Vision Science & …, 2022 - iovs.arvojournals.org
Purpose: Dual-specificity phosphatase 4 (DUSP4) inactivates factors in the mitogen-activated
protein kinase (MAPK) signaling cascade, activated in uveal melanoma (UM) by mutations …
protein kinase (MAPK) signaling cascade, activated in uveal melanoma (UM) by mutations …
[HTML][HTML] Results of an open-label phase 1b study of the ERK inhibitor MK-8353 plus the MEK inhibitor selumetinib in patients with advanced or metastatic solid tumors
A Stathis, AW Tolcher, JS Wang, DJ Renouf… - Investigational New …, 2023 - Springer
Aim: We evaluated MK-8353 (small molecule inhibitor of extracellular signal-regulated kinase
1/2) plus selumetinib (mitogen-activated extracellular signal-regulated kinase 1/2 inhibitor) …
1/2) plus selumetinib (mitogen-activated extracellular signal-regulated kinase 1/2 inhibitor) …
Combination Strategies to Overcome Resistance to Targeted Therapy in Gnaq/11-Mutant Melanoma
A Truong - 2020 - search.proquest.com
… contribute to uveal melanoma growth and survival, clinical trials utilizing targeted therapy of
… Patient-derived xenograft (PDX) models are considered one of the more superior models to …
… Patient-derived xenograft (PDX) models are considered one of the more superior models to …