[HTML][HTML] Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway

C Li, L Wan, P Wang, X Guan, C Li… - … of Musculoskeletal & …, 2021 - ncbi.nlm.nih.gov
Semaphorins are related to immune response, cell migration, … Semaphorin 4D (Sema4D) is
an important member of the … been reported to induce vascular endothelial cell migration and …

Semaphorin 4D as a guidance molecule in the immune system

E Kuklina - International Reviews of Immunology, 2021 - Taylor & Francis
… to Plexin B1 in COS-7 cells enhances the Sema4D-induced activation of RhoA and …
endothelial cells, dependent both on Met [Citation6] and on the non-receptor tyrosine kinases Pyk2

Emerging roles and mechanisms of semaphorins activity in cancer

C Bica, A Tirpe, A Nutu, C Ciocan, S Chira, ES Gurzau… - Life Sciences, 2023 - Elsevier
… – intracellular tyrosine kinases such as PYK2, FAK, Src family … -Fc successfully repressed
cell migration induced by VEGF, thus … angiogenesis through stimulation of endothelial cells (…

[HTML][HTML] Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells

N Al Turkestani, Z Zhang, JE Nör - Dentistry Journal, 2023 - mdpi.com
… unstimulated and SEMA4D-stimulated endothelial cells [54]. … activation by SEMA4D
induces angiogenesis, cytoskeletal reorganization, and the migration of endothelial cells through

[HTML][HTML] SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling

L Liu, L Yang, X Liu, M Liu, J Liu, X Feng, Z Nie… - Journal of Translational …, 2022 - Springer
… to the IV class of the subfamily of semaphorin family. Previous studies have reported that …
reducing the expression of SEMA4D induces apoptosis and limits the cell growth of AML. …

Identification and characterization of critical determinants in plexin signaling

CW Höß - 2020 - archiv.ub.uni-marburg.de
… 2005), in endothelial cell migration via the phosphatidylinositol 3-… PDZ-RHOGEF-RHO
mediated Semaphorin 4D-Plexin-B1 … that can induce dimerization after semaphorin stimulation, as …

A comprehensive review of tumor proliferative and suppressive role of semaphorins and therapeutic approaches

I Ahammad - Biophysical Reviews, 2020 - Springer
… C-terminal, and consequently induces cancer cell migration. One group of researchers that
… Experiments show that the soluble form of sema4D increases endothelial cell migration and …

[HTML][HTML] SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization

Y Cui, X Jiang, M Yang, Y Yuan, Z Zhou, X Gao, G Jia… - Materials Today Bio, 2023 - Elsevier
semaphorin protein family, and is one of so called “immune … endothelial growth factor (VEGF)
is an endothelial cell-… Besides, SEMA 4D-Plexin B1 interaction promotes the formation of …

[HTML][HTML] Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3

TT Le, SL Payne, MN Buckwald, LA Hayes… - NPJ breast …, 2022 - nature.com
… the semaphorin receptor PlexinB3 in cancer cells attenuate … migration and metastasis by
inducing a shift in TNBC cell … is present, promoting migration in HMEC-1 endothelial cells 39,56 …

Sensory nerves enhance triple-negative breast cancer migration and metastasis via the axon guidance molecule PlexinB3

TT Le, SL Payne, MN Buckwald, LA Hayes, CB Burge… - bioRxiv, 2021 - biorxiv.org
… cancer migration and metastasis by inducing a shift in TNBC cell … The semaphorin and plexin
family is emerging as an … is present, promoting migration in HMEC-1 endothelial cells 33,48 …