Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges
… cell membrane receptors which are classified into many groups. Serotonin receptors are …
belong to the family of either G protein-coupled receptors (GPCRs) or ligand-gated ion channels…
belong to the family of either G protein-coupled receptors (GPCRs) or ligand-gated ion channels…
[HTML][HTML] Role of serotonin receptor signaling in cancer cells and anti-tumor immunity
S Karmakar, G Lal - Theranostics, 2021 - ncbi.nlm.nih.gov
… immune cells and the nervous system through serotonin and its receptors (5-HTRs) in … by
serotonin is not well explored. In this review, we discuss how serotonin and serotonin receptors …
serotonin is not well explored. In this review, we discuss how serotonin and serotonin receptors …
Serotonin receptors in epilepsy: Novel treatment targets?
J Sourbron, L Lagae - Epilepsia Open, 2022 - Wiley Online Library
… have underlined that serotonergic receptors seem to be an … of the 14 different serotonin
receptors and its role in epilepsy … serotonin receptor in the pathology/treatment of epilepsy. …
receptors and its role in epilepsy … serotonin receptor in the pathology/treatment of epilepsy. …
Structural insights into the lipid and ligand regulation of serotonin receptors
… 5-HT receptors have high levels of basal activity and are subject to regulation by … receptors
and the pan-agonism of 5-HT remains unclear. Here we report five structures of 5-HT receptor…
and the pan-agonism of 5-HT remains unclear. Here we report five structures of 5-HT receptor…
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
… Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12
different G protein-coupled receptors … Here, we report the structures of the serotonin receptors …
different G protein-coupled receptors … Here, we report the structures of the serotonin receptors …
[HTML][HTML] Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD
… (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential … 2A serotonin
receptor (HTR2A), the 5-HT 2B serotonin receptor (HTR2B) has been used as a model receptor to …
receptor (HTR2A), the 5-HT 2B serotonin receptor (HTR2B) has been used as a model receptor to …
Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors
… Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors
(5-HTRs). … Both alkaloids produced antinociceptive properties in rats via an opioid receptor-…
(5-HTRs). … Both alkaloids produced antinociceptive properties in rats via an opioid receptor-…
Serotonin receptor 4 in the hippocampus modulates mood and anxiety
Serotonin receptor 4 (5-HT 4 R) plays an important role in regulating mood, anxiety, and
cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects …
cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects …
Enhancing the antipsychotic effect of risperidone by increasing its binding affinity to serotonin receptor via picric acid: A molecular dynamics simulation
… receptor profile drug targeting the relevant receptors [11]. Previous animal studies showed
that higher Ris affinity to dopamine receptors … than that of serotonin receptors fits with study …
that higher Ris affinity to dopamine receptors … than that of serotonin receptors fits with study …
[HTML][HTML] Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor
… How psychedelics mediate their actions—both therapeutic and hallucinogenic—are not
understood, although activation of the 5-HT 2A serotonin receptor (HTR2A) is key. To gain …
understood, although activation of the 5-HT 2A serotonin receptor (HTR2A) is key. To gain …